Ndor1 NADPH dependent diflavin oxidoreductase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ndor1provided by RGD
Official Full Name: NADPH dependent diflavin oxidoreductase 1provided by RGD
Primary source: RGD:1308479
See related: Ensembl:ENSRNOG00000010616 AllianceGenome:RGD:1308479
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including NADPH-hemoprotein reductase activity; nucleotide binding activity; and oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor. Predicted to be involved in cell death; cellular response to menadione; and electron transport chain. Predicted to be located in cytoplasm; intermediate filament cytoskeleton; and nucleoplasm. Predicted to be active in cytosol. Orthologous to human NDOR1 (NADPH dependent diflavin oxidoreductase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 59.9), Adrenal (RPKM 59.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3p13

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (28460787..28469018, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (8062629..8070873, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (2466698..2474928, complement)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

analysis of the structure of NADPH-cytochrome P450 oxidoreductase in an open conformation capable of reducing cytochrome P450
Title: Structure and function of an NADPH-cytochrome P450 oxidoreductase in an open conformation capable of reducing cytochrome P450.

Submit: New GeneRIF Correction

General gene information

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Markers

RH132140 (e-PCR)
- UniSTS:215423

RH141138 (e-PCR)
- UniSTS:223134

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables FAD binding	ISO Inferred from Sequence Orthology more info
enables FMN binding	IBA Inferred from Biological aspect of Ancestor more info
enables FMN binding	ISO Inferred from Sequence Orthology more info
enables NADP binding	ISO Inferred from Sequence Orthology more info
enables NADPH binding	ISO Inferred from Sequence Orthology more info
enables NADPH-hemoprotein reductase activity	ISO Inferred from Sequence Orthology more info
enables electron transfer activity	ISO Inferred from Sequence Orthology more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in electron transport chain	ISO Inferred from Sequence Orthology more info
involved_in iron-sulfur cluster assembly	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intermediate filament cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in intermediate filament cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: NADPH-dependent diflavin oxidoreductase 1

NP_001101288.1

EC 1.6.-.-

XP_038961126.1

EC 1.6.-.-

XP_038961127.1

EC 1.6.-.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107818.1 → NP_001101288.1 NADPH-dependent diflavin oxidoreductase 1

See identical proteins and their annotated locations for NP_001101288.1

Status: PROVISIONAL

Source sequence(s)

CH474001

UniProtKB/TrEMBL

A0A8I6A1U1, A6JT23, D4ABT4

Related

ENSRNOP00000014445.3, ENSRNOT00000014445.5

Conserved Domains (1) summary

COG0369
Location:6 → 597

CysJ; Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

28460787..28469018 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105198.2 → XP_038961126.1 NADPH-dependent diflavin oxidoreductase 1 isoform X1

UniProtKB/TrEMBL

A0A8I6A985

Conserved Domains (1) summary

cl06868
Location:59 → 444

FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...
XM_039105199.2 → XP_038961127.1 NADPH-dependent diflavin oxidoreductase 1 isoform X2

Conserved Domains (1) summary

cl06868
Location:6 → 415

FNR_like; Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport ...