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Gsap gamma-secretase activating protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 311984, updated on 13-Apr-2024

Summary

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Official Symbol
Gsapprovided by RGD
Official Full Name
gamma-secretase activating proteinprovided by RGD
Primary source
RGD:1563271
See related
Ensembl:ENSRNOG00000028801 AllianceGenome:RGD:1563271
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pion
Summary
Predicted to enable amyloid-beta binding activity. Predicted to be involved in positive regulation of amyloid-beta formation and regulation of proteolysis. Predicted to be active in trans-Golgi network. Orthologous to human GSAP (gamma-secretase activating protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 130.5), Lung (RPKM 106.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gsap in Genome Data Viewer
Location:
4q11
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (14705237..14800057, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (13813046..13907875, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (10423090..10517887, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 146 Neighboring gene fibrinogen-like 2 Neighboring gene uncharacterized LOC120102212 Neighboring gene neuroepithelial cell transforming 1, pseudogene 1 Neighboring gene small nucleolar RNA SNORA40

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The role of γ-secretase activating protein (GSAP) and imatinib in the regulation of γ-secretase activity and amyloid-β generation. Hussain I, et al. J Biol Chem, 2013 Jan 25. PMID 23209290, Free PMC Article
  2. Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease. He G, et al. Nature, 2010 Sep 2. PMID 20811458, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. gamma-secretase activating protein (GSAP) and imatinib have roles in the regulation of gamma-secretase activity and amyloid-beta generation
    Title: The role of γ-secretase activating protein (GSAP) and imatinib in the regulation of γ-secretase activity and amyloid-β generation.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables amyloid-beta binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in positive regulation of amyloid-beta formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of proteolysis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
gamma-secretase-activating protein
Names
pigeon homolog
protein pigeon homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395028.2 → NP_001381957.1  gamma-secretase-activating protein

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A0G2JWZ3, A0A8I6A0P7, A6K5C2
    Related
    ENSRNOP00000070072.1, ENSRNOT00000083964.2
    Conserved Domains (1) summary
    pfam14959
    Location:634 → 741
    GSAP-16; gamma-Secretase-activating protein C-term

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    14705237..14800057 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008762649.4 → XP_008760871.1  gamma-secretase-activating protein isoform X1

    UniProtKB/TrEMBL
    A0A8I6A0P7
    Conserved Domains (1) summary
    pfam14959
    Location:634 → 741
    GSAP-16; gamma-Secretase-activating protein C-term

  2. XM_063285956.1 → XP_063142026.1  gamma-secretase-activating protein isoform X2

  3. XM_039107498.2 → XP_038963426.1  gamma-secretase-activating protein isoform X3

RNA

  1. XR_005503210.2 RNA Sequence

  2. XR_005503209.2 RNA Sequence

  3. XR_010065635.1 RNA Sequence

  4. XR_010065636.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001107845.1: Suppressed sequence

    Description
    NM_001107845.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version

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