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Rbm28 RNA binding motif protein 28 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312182, updated on 2-May-2024

Summary

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Official Symbol
Rbm28provided by RGD
Official Full Name
RNA binding motif protein 28provided by RGD
Primary source
RGD:1311336
See related
Ensembl:ENSRNOG00000005468 AllianceGenome:RGD:1311336
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable RNA binding activity. Predicted to be located in nucleolus. Predicted to be part of ribonucleoprotein complex. Human ortholog(s) of this gene implicated in alopecia, neurologic defects, and endocrinopathy syndrome. Orthologous to human RBM28 (RNA binding motif protein 28). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 48.2), Thymus (RPKM 47.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rbm28 in Genome Data Viewer
Location:
4q22
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (58688337..58727312, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (57722946..57761935, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (56398769..56438442, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102250 Neighboring gene microRNA 129-1 Neighboring gene leptin Neighboring gene proline-rich transmembrane protein 4 Neighboring gene inosine monophosphate dehydrogenase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Both endonucleolytic and exonucleolytic cleavage mediate ITS1 removal during human ribosomal RNA processing. Sloan KE, et al. J Cell Biol, 2013 Mar 4. PMID 23439679, Free PMC Article
  2. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
  3. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RNA-binding protein 28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107850.2 → NP_001101320.1  RNA-binding protein 28 isoform 1

    See identical proteins and their annotated locations for NP_001101320.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A0A0G2JVD0, A6IEB7
    Related
    ENSRNOP00000069435.1, ENSRNOT00000077079.2
    Conserved Domains (5) summary
    cd12413
    Location:5 → 78
    RRM1_RBM28_like; RNA recognition motif 1 in RNA-binding protein 28 (RBM28) and similar proteins
    cd12414
    Location:115 → 190
    RRM2_RBM28_like; RNA recognition motif 2 in RNA-binding protein 28 (RBM28) and similar proteins
    cd12415
    Location:329 → 411
    RRM3_RBM28_like; RNA recognition motif 3 in RNA-binding protein 28 (RBM28) and similar proteins
    cd12416
    Location:458 → 522
    RRM4_RBM28_like; RNA recognition motif 4 in RNA-binding protein 28 (RBM28) and similar proteins
    TIGR01661
    Location:6 → 408
    ELAV_HUD_SF; ELAV/HuD family splicing factor

  2. NM_001415878.1 → NP_001402807.1  RNA-binding protein 28 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    58688337..58727312 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107509.2 → XP_038963437.1  RNA-binding protein 28 isoform X2

    UniProtKB/TrEMBL
    D4A5K7
    Related
    ENSRNOP00000059579.3
    Conserved Domains (5) summary
    TIGR01628
    Location:303 → 690
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    COG0724
    Location:33 → 202
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12414
    Location:96 → 171
    RRM2_RBM28_like; RNA recognition motif 2 (RRM2) found in RNA-binding protein 28 (RBM28) and similar proteins
    cd12415
    Location:310 → 392
    RRM3_RBM28_like; RNA recognition motif 3 (RRM3) found in RNA-binding protein 28 (RBM28) and similar proteins
    cd12416
    Location:462 → 556
    RRM4_RBM28_like; RNA recognition motif 4 (RRM4) found in RNA-binding protein 28 (RBM28) and similar proteins

  2. XM_006236190.5 → XP_006236252.1  RNA-binding protein 28 isoform X1

    UniProtKB/TrEMBL
    D4A5K7
    Conserved Domains (6) summary
    TIGR01628
    Location:322 → 709
    PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
    cd12413
    Location:5 → 78
    RRM1_RBM28_like; RNA recognition motif 1 in RNA-binding protein 28 (RBM28) and similar proteins
    cd12414
    Location:115 → 190
    RRM2_RBM28_like; RNA recognition motif 2 in RNA-binding protein 28 (RBM28) and similar proteins
    cd12415
    Location:329 → 411
    RRM3_RBM28_like; RNA recognition motif 3 in RNA-binding protein 28 (RBM28) and similar proteins
    cd12416
    Location:481 → 575
    RRM4_RBM28_like; RNA recognition motif 4 in RNA-binding protein 28 (RBM28) and similar proteins
    TIGR01661
    Location:6 → 408
    ELAV_HUD_SF; ELAV/HuD family splicing factor
Nucleotide Protein Strain
Heading Accession and Version

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