U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ephb6 Eph receptor B6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312275, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Symbol
Ephb6provided by RGD
Full Name
Eph receptor B6provided by RGD
Primary source
RGD:1306163
See related
Ensembl:ENSRNOG00000014367 AllianceGenome:RGD:1306163
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable transmembrane-ephrin receptor activity. Predicted to be involved in axonogenesis; positive regulation of kinase activity; and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to act upstream of or within several processes, including activated T cell proliferation; positive regulation of T cell costimulation; and type IV hypersensitivity. Predicted to be located in cell surface. Predicted to be part of receptor complex. Predicted to be active in neuron projection. Predicted to be integral component of plasma membrane. Orthologous to human EPHB6 (EPH receptor B6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 548.0), Adrenal (RPKM 241.7) and 3 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Ephb6 in Genome Data Viewer
Location:
4q23
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (71458632..71473889)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (70491973..70507230)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (70903253..70918514)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120102259 Neighboring gene U6 spliceosomal RNA Neighboring gene transient receptor potential cation channel, subfamily V, member 6 Neighboring gene transient receptor potential cation channel, subfamily V, member 5

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The receptor tyrosine kinase EphB2 promotes hepatic fibrosis in mice. Mimche PN, et al. Hepatology, 2015 Sep. PMID 25784101, Free PMC Article
  2. EphB6-null mutation results in compromised T cell function. Luo H, et al. J Clin Invest, 2004 Dec. PMID 15599401, Free PMC Article
  3. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Gibbs RA, et al. Nature, 2004 Apr 1. PMID 15057822
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane-ephrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within T cell mediated immunity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within activated T cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ephrin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of T cell costimulation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within type IV hypersensitivity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ephrin type-B receptor 6
Names
serine/arginine repetitive matrix protein 2-like
tyrosine-protein kinase-defective receptor EPH-6
NP_001101327.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107857.1 → NP_001101327.1  ephrin type-B receptor 6 precursor

    See identical proteins and their annotated locations for NP_001101327.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473959
    UniProtKB/Swiss-Prot
    P0C0K7
    UniProtKB/TrEMBL
    A6IF46
    Related
    ENSRNOP00000019720.4, ENSRNOT00000019720.6
    Conserved Domains (8) summary
    cd09555
    Location:937 → 1005
    SAM_EPH-B6; SAM domain of EPH-B6 subfamily of tyrosine kinase receptors
    smart00454
    Location:938 → 1004
    SAM; Sterile alpha motif
    cd10475
    Location:33 → 225
    EphR_LBD_B6; Ligand Binding Domain of Ephrin type-B Receptor 6
    cd00063
    Location:480 → 571
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd00185
    Location:294 → 361
    TNFRSF; Tumor necrosis factor receptor superfamily (TNFRSF)
    pfam07714
    Location:662 → 907
    Pkinase_Tyr; Protein tyrosine kinase
    pfam14575
    Location:604 → 657
    EphA2_TM; Ephrin type-A receptor 2 transmembrane domain
    cl21453
    Location:657 → 911
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    71458632..71473889
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P0C0K7.3 GenPept UniProtKB/Swiss-Prot:P0C0K7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous