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Tmcc1 transmembrane and coiled-coil domain family 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312654, updated on 3-Apr-2024

Summary

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Official Symbol
Tmcc1provided by RGD
Official Full Name
transmembrane and coiled-coil domain family 1provided by RGD
Primary source
RGD:1311909
See related
Ensembl:ENSRNOG00000011614 AllianceGenome:RGD:1311909
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1311909
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including endosome fission; endosome membrane tubulation; and membrane fission. Predicted to be located in cytosol; endoplasmic reticulum-endosome membrane contact site; and rough endoplasmic reticulum. Predicted to be active in endomembrane system. Orthologous to human TMCC1 (transmembrane and coiled-coil domain family 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 88.8), Muscle (RPKM 83.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tmcc1 in Genome Data Viewer
Location:
4q42
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (150738966..150912256, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (149069252..149239585, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (147920987..148048852, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene plexin D1 Neighboring gene H1.8 linker histone Neighboring gene small RNA binding exonuclease protection factor La like 1 Neighboring gene WASH complex subunit 2C Neighboring gene ribosomal protein L9, pseudogene 19 Neighboring gene zinc finger AN1-type containing 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A Novel Class of ER Membrane Proteins Regulates ER-Associated Endosome Fission. Hoyer MJ, et al. Cell, 2018 Sep 20. PMID 30220460, Free PMC Article
  2. Transmembrane and coiled-coil domain family 1 is a novel protein of the endoplasmic reticulum. Zhang C, et al. PLoS One, 2014. PMID 24454821, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in endoplasmic reticulum organization ISO
Inferred from Sequence Orthology
more info
  
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosomal transport ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome fission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosome fission ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome membrane tubulation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endosome membrane tubulation ISO
Inferred from Sequence Orthology
more info
  
involved_in membrane fission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in membrane fission ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum-endosome membrane contact site ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in rough endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transmembrane and coiled-coil domains protein 1
Names
transmembrane and coiled coil domains 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427270.2 → NP_001414199.1  transmembrane and coiled-coil domains protein 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    D3ZH14

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    150738966..150912256 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286097.1 → XP_063142167.1  transmembrane and coiled-coil domains protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ABR1

  2. XM_039109036.2 → XP_038964964.1  transmembrane and coiled-coil domains protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ABR1
    Related
    ENSRNOP00000090083.1
    Conserved Domains (1) summary
    pfam10267
    Location:271 → 678
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  3. XM_063286099.1 → XP_063142169.1  transmembrane and coiled-coil domains protein 1 isoform X2

    UniProtKB/TrEMBL
    D3ZH14

  4. XM_063286096.1 → XP_063142166.1  transmembrane and coiled-coil domains protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ABR1

  5. XM_063286100.1 → XP_063142170.1  transmembrane and coiled-coil domains protein 1 isoform X2

    UniProtKB/TrEMBL
    D3ZH14

  6. XM_063286098.1 → XP_063142168.1  transmembrane and coiled-coil domains protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ABR1

  7. XM_006237071.5 → XP_006237133.1  transmembrane and coiled-coil domains protein 1 isoform X4

    See identical proteins and their annotated locations for XP_006237133.1

    UniProtKB/TrEMBL
    A0A8I6GKA4
    Related
    ENSRNOP00000092679.1
    Conserved Domains (1) summary
    pfam10267
    Location:52 → 459
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  8. XM_006237072.5 → XP_006237134.1  transmembrane and coiled-coil domains protein 1 isoform X5

    See identical proteins and their annotated locations for XP_006237134.1

    UniProtKB/TrEMBL
    A0A8I6AFS3, A6IL07
    Related
    ENSRNOP00000093411.1
    Conserved Domains (1) summary
    pfam10267
    Location:51 → 455
    Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

  9. XM_017593028.3 → XP_017448517.1  transmembrane and coiled-coil domains protein 1 isoform X3

  10. XM_063286102.1 → XP_063142172.1  transmembrane and coiled-coil domains protein 1 isoform X6

    UniProtKB/TrEMBL
    A6IL08
Nucleotide Protein Strain
Heading Accession and Version

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