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Ankrd26 ankyrin repeat domain containing 26 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312667, updated on 5-Mar-2024

Summary

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Official Symbol
Ankrd26provided by RGD
Official Full Name
ankyrin repeat domain containing 26provided by RGD
Primary source
RGD:1310736
See related
Ensembl:ENSRNOG00000006717 AllianceGenome:RGD:1310736
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1310736
Summary
Predicted to act upstream of or within several processes, including glucose homeostasis; negative regulation of fat cell differentiation; and negative regulation of signal transduction. Predicted to be located in actin cytoskeleton and centrosome. Human ortholog(s) of this gene implicated in thrombocytopenia. Orthologous to several human genes including ANKRD26 (ankyrin repeat domain 26). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 54.1), Brain (RPKM 49.3) and 9 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4q42
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (153342901..153412321, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (151670604..151740032, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (150548656..150616928, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486626 Neighboring gene U4 spliceosomal RNA Neighboring gene zinc finger protein 248 Neighboring gene zinc finger protein 9 Neighboring gene uncharacterized LOC134486629 Neighboring gene calcium voltage-gated channel subunit alpha1 C Neighboring gene uncharacterized LOC134486627

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Partial inactivation of Ankrd26 causes diabetes with enhanced insulin responsiveness of adipose tissue in mice. Raciti GA, et al. Diabetologia, 2011 Nov. PMID 21842266, Free PMC Article
  2. Mutations in ANKRD26 are responsible for a frequent form of inherited thrombocytopenia: analysis of 78 patients from 21 families. Noris P, et al. Blood, 2011 Jun 16. PMID 21467542
  3. Ankrd26 gene disruption enhances adipogenesis of mouse embryonic fibroblasts. Fei Z, et al. J Biol Chem, 2011 Aug 5. PMID 21669876, Free PMC Article
  4. A model for obesity and gigantism due to disruption of the Ankrd26 gene. Bera TK, et al. Proc Natl Acad Sci U S A, 2008 Jan 8. PMID 18162531, Free PMC Article
  5. ANKRD26 and its interacting partners TRIO, GPS2, HMMR and DIPA regulate adipogenesis in 3T3-L1 cells. Liu XF, et al. PLoS One, 2012. PMID 22666460, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glucose homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of organ growth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of organ growth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of feeding behavior ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of lipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ankyrin repeat domain-containing protein 26; ankyrin repeat domain-containing protein 30A
Names
ankyrin repeat domain 26

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    153342901..153412321 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108799.2 → XP_038964727.1  ankyrin repeat domain-containing protein 30A isoform X3

    UniProtKB/TrEMBL
    A6IL65
    Conserved Domains (6) summary
    PTZ00322
    Location:105 → 201
    PTZ00322; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
    COG1196
    Location:735 → 1523
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    sd00045
    Location:57 → 86
    ANK; ANK repeat [structural motif]
    pfam12001
    Location:1464 → 1571
    DUF3496; Domain of unknown function (DUF3496)
    pfam12796
    Location:60 → 152
    Ank_2; Ankyrin repeats (3 copies)
    pfam14915
    Location:855 → 1159
    CCDC144C; CCDC144C protein coiled-coil region

  2. XM_232319.10 → XP_232319.5  ankyrin repeat domain-containing protein 30A isoform X1

    UniProtKB/TrEMBL
    A6IL65, M0R3T8
    Related
    ENSRNOP00000064010.2
    Conserved Domains (8) summary
    cd00204
    Location:75 → 200
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08287
    Location:1213 → 1314
    DASH_Spc19; Spc19
    pfam12001
    Location:1489 → 1596
    DUF3496; Domain of unknown function (DUF3496)
    pfam12796
    Location:85 → 177
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:51 → 101
    Ank_4; Ankyrin repeats (many copies)
    pfam14915
    Location:880 → 1183
    CCDC144C; CCDC144C protein coiled-coil region
    pfam15290
    Location:787 → 922
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
    sd00045
    Location:82 → 111
    ANK; ANK repeat [structural motif]

  3. XM_006237217.5 → XP_006237279.1  ankyrin repeat domain-containing protein 30A isoform X4

    UniProtKB/TrEMBL
    A0A8I6AJ86, A6IL65
    Related
    ENSRNOP00000093066.1
    Conserved Domains (8) summary
    cd00204
    Location:75 → 200
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08287
    Location:1180 → 1281
    DASH_Spc19; Spc19
    pfam12001
    Location:1456 → 1563
    DUF3496; Domain of unknown function (DUF3496)
    pfam12796
    Location:85 → 177
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:51 → 101
    Ank_4; Ankyrin repeats (many copies)
    pfam14915
    Location:847 → 1150
    CCDC144C; CCDC144C protein coiled-coil region
    pfam15290
    Location:754 → 889
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
    sd00045
    Location:82 → 111
    ANK; ANK repeat [structural motif]

  4. XM_008763271.4 → XP_008761493.1  ankyrin repeat domain-containing protein 30A isoform X2

    UniProtKB/TrEMBL
    A6IL65
    Conserved Domains (9) summary
    COG0419
    Location:993 → 1561
    SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
    cd00204
    Location:75 → 200
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam08287
    Location:1213 → 1314
    DASH_Spc19; Spc19
    pfam12001
    Location:1483 → 1590
    DUF3496; Domain of unknown function (DUF3496)
    pfam12796
    Location:85 → 177
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:51 → 101
    Ank_4; Ankyrin repeats (many copies)
    pfam14915
    Location:880 → 1183
    CCDC144C; CCDC144C protein coiled-coil region
    pfam15290
    Location:787 → 922
    Syntaphilin; Golgi-localized syntaxin-1-binding clamp
    sd00045
    Location:82 → 111
    ANK; ANK repeat [structural motif]
Nucleotide Protein Strain
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