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Cops5 COP9 signalosome subunit 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312916, updated on 5-Mar-2024

Summary

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Official Symbol
Cops5provided by RGD
Official Full Name
COP9 signalosome subunit 5provided by RGD
Primary source
RGD:1310301
See related
Ensembl:ENSRNOG00000006499 AllianceGenome:RGD:1310301
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable enzyme binding activity; macrophage migration inhibitory factor binding activity; and peptidase activity. Predicted to be involved in several processes, including protein modification by small protein removal; regulation of cellular response to stress; and regulation of transcription, DNA-templated. Predicted to act upstream of or within regulation of cell cycle. Predicted to be located in several cellular components, including nucleoplasm; perinuclear region of cytoplasm; and synaptic vesicle. Predicted to be part of COP9 signalosome. Predicted to be active in cytoplasm. Predicted to colocalize with chromatin. Orthologous to human COPS5 (COP9 signalosome subunit 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 529.0), Testes (RPKM 471.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q11
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (13975198..13993391)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (9192233..9210498)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (8876090..8894345)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene ADP ribosylation factor guanine nucleotide exchange factor 1 Neighboring gene uncharacterized LOC134486914 Neighboring gene uncharacterized LOC134486913 Neighboring gene centrosome and spindle pole associated protein 1 Neighboring gene RNA, U6 small nuclear 1297 Neighboring gene protein phosphatase 1, regulatory subunit 42

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Porcine JAB1 significantly enhances apoptosis induced by staurosporine. Jiang P, et al. Cell Death Dis, 2013 Oct 3. PMID 24091666, Free PMC Article
  2. COP9-associated CSN5 regulates exosomal protein deubiquitination and sorting. Liu Y, et al. Am J Pathol, 2009 Apr. PMID 19246649, Free PMC Article
  3. Down-regulation of the cyclin-dependent kinase inhibitor p57 is mediated by Jab1/Csn5 in hepatocarcinogenesis. Guo H, et al. Hepatology, 2016 Mar. PMID 26606000
  4. Fank1 interacts with Jab1 and regulates cell apoptosis via the AP-1 pathway. Wang H, et al. Cell Mol Life Sci, 2011 Jun. PMID 20978819
  5. RIG-G as a key mediator of the antiproliferative activity of interferon-related pathways through enhancing p21 and p27 proteins. Xiao S, et al. Proc Natl Acad Sci U S A, 2006 Oct 31. PMID 17050680, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Jab1 provides a novel signal transduction pathway for 5-HT(6)R and may play an important role in 5-HT(6)R-mediated behavior changes in the brain
    Title: Physical interaction of Jab1 with human serotonin 6 G-protein-coupled receptor and their possible roles in cell survival.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC112728

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables deNEDDylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables macrophage migration inhibitory factor binding ISO
Inferred from Sequence Orthology
more info
  
enables metal-dependent deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables metallopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in exosomal secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deneddylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein deneddylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of IRE1-mediated unfolded protein response ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of JNK cascade ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of COP9 signalosome ISO
Inferred from Sequence Orthology
more info
  
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
COP9 signalosome complex subunit 5
Names
COP9 (constitutive photomorphogenic) homolog, subunit 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025695.1 → NP_001020866.1  COP9 signalosome complex subunit 5

    See identical proteins and their annotated locations for NP_001020866.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098736
    UniProtKB/TrEMBL
    A0A8I5ZYE7, Q4KM69
    Related
    ENSRNOP00000008877.5, ENSRNOT00000008877.7
    Conserved Domains (1) summary
    cd08069
    Location:44 → 314
    MPN_RPN11_CSN5; Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    13975198..13993391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006237758.5 → XP_006237820.1  COP9 signalosome complex subunit 5 isoform X1

    Conserved Domains (1) summary
    cd08069
    Location:33 → 297
    MPN_RPN11_CSN5; Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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