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Pm20d2 peptidase M20 domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313130, updated on 30-Mar-2024

Summary

Official Symbol
Pm20d2provided by RGD
Official Full Name
peptidase M20 domain containing 2provided by RGD
Primary source
RGD:1307853
See related
Ensembl:ENSRNOG00000007755 AllianceGenome:RGD:1307853
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Acy1l2
Summary
Enables dipeptidase activity. Acts upstream of or within proteolysis. Predicted to be located in nucleoplasm. Orthologous to human PM20D2 (peptidase M20 domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 237.1), Kidney (RPKM 139.9) and 8 other tissues See more
Orthologs
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Genomic context

See Pm20d2 in Genome Data Viewer
Location:
5q21
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (52362384..52382647, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (47566059..47586334, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (48416005..48437054, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102555980 Neighboring gene gamma-aminobutyric acid type A receptor subunit rho 1 Neighboring gene U6 spliceosomal RNA Neighboring gene serine and arginine rich splicing factor 12 Neighboring gene proline-rich nuclear receptor coactivator 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables dipeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables dipeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables dipeptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
NOT enables para-aminobenzoyl-glutamate hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
NOT involved_in folic acid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within proteolysis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of protein metabolic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
NOT is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
xaa-Arg dipeptidase
Names
aminoacylase 1-like 2
peptidase M20 domain-containing protein 2
NP_001101392.2
XP_063143655.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107922.3NP_001101392.2  xaa-Arg dipeptidase

    See identical proteins and their annotated locations for NP_001101392.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    D4AAB5
    Related
    ENSRNOP00000057636.2, ENSRNOT00000060914.3
    Conserved Domains (1) summary
    cd05672
    Location:30401
    M20_ACY1L2-like; M20 Peptidase aminoacylase 1-like protein 2-like, amidohydrolase subfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    52362384..52382647 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287585.1XP_063143655.1  xaa-Arg dipeptidase isoform X1

RNA

  1. XR_005504433.2 RNA Sequence