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Coro2a coronin 2A [ Rattus norvegicus (Norway rat) ]

Gene ID: 313235, updated on 6-Jun-2024

Summary

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Official Symbol
Coro2aprovided by RGD
Official Full Name
coronin 2Aprovided by RGD
Primary source
RGD:1309719
See related
Ensembl:ENSRNOG00000008901 AllianceGenome:RGD:1309719
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin filament binding activity. Predicted to be located in brush border. Predicted to be part of transcription repressor complex. Orthologous to human CORO2A (coronin 2A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 42.1), Brain (RPKM 33.0) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Coro2a in Genome Data Viewer
Location:
5q22
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (65623820..65677483, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (60825630..60881917, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (62154526..62210797, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene N-acetylneuraminate synthase Neighboring gene tripartite motif-containing 14 Neighboring gene uncharacterized LOC108350963 Neighboring gene uncharacterized LOC108350962 Neighboring gene TBC1 domain family, member 2 Neighboring gene uncharacterized LOC120102869

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Coronin 2A regulates a subset of focal-adhesion-turnover events through the cofilin pathway. Marshall TW, et al. J Cell Sci, 2009 Sep 1. PMID 19654210, Free PMC Article
  2. Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. Yoon HG, et al. EMBO J, 2003 Mar 17. PMID 12628926, Free PMC Article
  3. A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins. Revenu C, et al. Mol Biol Cell, 2012 Jan. PMID 22114352, Free PMC Article
  4. Interactome analysis of AMP-activated protein kinase (AMPK)-α1 and -β1 in INS-1 pancreatic beta-cells by affinity purification-mass spectrometry. Moon S, et al. Sci Rep, 2014 Mar 14. PMID 24625528, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Coronin 2A and cofilin regulate a subset of focal-adhesion-turnover events.
    Title: Coronin 2A regulates a subset of focal-adhesion-turnover events through the cofilin pathway.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in brush border ISO
Inferred from Sequence Orthology
more info
  
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
coronin-2A
Names
coronin, actin binding protein 2A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012101.2 → NP_001012101.2  coronin-2A

    Status: VALIDATED

    Source sequence(s)
    BC079209, JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A0G2QC56, A6IJC5
    Related
    ENSRNOP00000011787.7, ENSRNOT00000011787.8
    Conserved Domains (6) summary
    PTZ00421
    Location:29 → 536
    PTZ00421; coronin; Provisional
    pfam08953
    Location:27 → 84
    DUF1899; Domain of unknown function (DUF1899)
    pfam13863
    Location:496 → 534
    DUF4200; Domain of unknown function (DUF4200)
    pfam16300
    Location:369 → 411
    WD40_4; Type of WD40 repeat
    sd00039
    Location:59 → 99
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:98 → 327
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    65623820..65677483 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006238058.5 → XP_006238120.1  coronin-2A isoform X2

    See identical proteins and their annotated locations for XP_006238120.1

    UniProtKB/TrEMBL
    A6IJC5, F1LSP7, Q6AY36
    Conserved Domains (2) summary
    sd00039
    Location:40 → 80
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:10 → 517
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_063287629.1 → XP_063143699.1  coronin-2A isoform X2

    UniProtKB/TrEMBL
    A6IJC5, F1LSP7, Q6AY36

  3. XM_017593364.3 → XP_017448853.1  coronin-2A isoform X1

    UniProtKB/TrEMBL
    A0A0G2QC56, A6IJC5
    Conserved Domains (6) summary
    PTZ00421
    Location:29 → 536
    PTZ00421; coronin; Provisional
    pfam08953
    Location:27 → 84
    DUF1899; Domain of unknown function (DUF1899)
    pfam13863
    Location:496 → 534
    DUF4200; Domain of unknown function (DUF4200)
    pfam16300
    Location:369 → 411
    WD40_4; Type of WD40 repeat
    sd00039
    Location:59 → 99
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:98 → 327
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_039109864.2 → XP_038965792.1  coronin-2A isoform X2

    UniProtKB/TrEMBL
    A6IJC5, F1LSP7, Q6AY36
    Conserved Domains (2) summary
    sd00039
    Location:40 → 80
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:10 → 517
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein Strain
Heading Accession and Version

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