Rgp1 RGP1 homolog, RAB6A GEF complex partner 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rgp1provided by RGD
Official Full Name: RGP1 homolog, RAB6A GEF complex partner 1provided by RGD
Primary source: RGD:1311757
See related: Ensembl:ENSRNOG00000016309 AllianceGenome:RGD:1311757
Gene type: protein coding
RefSeq status: INFERRED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311757
Summary: Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in negative regulation of cellular protein catabolic process; positive regulation of GTPase activity; and retrograde transport, endosome to Golgi. Predicted to be located in cytosol and plasma membrane. Predicted to be part of Ric1-Rgp1 guanyl-nucleotide exchange factor complex. Predicted to be active in Golgi membrane. Orthologous to human RGP1 (RGP1 homolog, RAB6A GEF complex partner 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 102.2), Heart (RPKM 86.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q22

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (62630253..62638872)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (57834467..57843087)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (59080290..59088777)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde transport, endosome to Golgi	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of Ric1-Rgp1 guanyl-nucleotide exchange factor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Ric1-Rgp1 guanyl-nucleotide exchange factor complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RAB6A-GEF complex partner protein 2

Names: RGP1 retrograde golgi transport homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001399573.1 → NP_001386502.1 RAB6A-GEF complex partner protein 2

Status: INFERRED

Source sequence(s)

JAXUCZ010000005

Related

ENSRNOP00000085271.1, ENSRNOT00000114536.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

62630253..62638872

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039111010.2 → XP_038966938.1 RAB6A-GEF complex partner protein 2 isoform X1

UniProtKB/TrEMBL

A0A8I5ZYV2

Conserved Domains (1) summary

pfam08737
Location:117 → 357

Rgp1