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Hectd3 HECT domain E3 ubiquitin protein ligase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313525, updated on 13-Apr-2024

Summary

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Official Symbol
Hectd3provided by RGD
Official Full Name
HECT domain E3 ubiquitin protein ligase 3provided by RGD
Primary source
RGD:1309823
See related
Ensembl:ENSRNOG00000018363 AllianceGenome:RGD:1309823
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309823
Summary
Predicted to enable syntaxin binding activity and ubiquitin-protein transferase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be located in perinuclear region of cytoplasm. Orthologous to human HECTD3 (HECT domain E3 ubiquitin protein ligase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 70.9), Brain (RPKM 62.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Hectd3 in Genome Data Viewer
Location:
5q36
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (135706437..135715173)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (130469840..130479802)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (135860578..135870535)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene zinc finger, SWIM-type containing 5 Neighboring gene large ribosomal subunit protein eL18-like Neighboring gene 40S ribosomal protein S12-like Neighboring gene uroporphyrinogen decarboxylase Neighboring gene eukaryotic translation initiation factor 2B subunit gamma Neighboring gene small ribosomal subunit protein uS10-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The E3 ubiquitin ligase HECTD3 regulates ubiquitination and degradation of Tara. Yu J, et al. Biochem Biophys Res Commun, 2008 Mar 21. PMID 18194665
  2. Interaction between syntaxin 8 and HECTd3, a HECT domain ligase. Zhang L, et al. Cell Mol Neurobiol, 2009 Feb. PMID 18821010
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables syntaxin binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase HECTD3
Names
HECT domain containing E3 ubiquitin protein ligase 3
NP_001386141.1
XP_038967444.1
XP_038967445.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399212.1 → NP_001386141.1  E3 ubiquitin-protein ligase HECTD3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    F1LVZ9
    Related
    ENSRNOP00000024737.7, ENSRNOT00000024737.8
    Conserved Domains (2) summary
    cd08666
    Location:238 → 371
    APC10-HECTD3; APC10-like DOC1 domain of HECTD3, a HECT E3 ubiquitin ligase protein that mediates substrate ubiquitination
    pfam00632
    Location:579 → 845
    HECT; HECT-domain (ubiquitin-transferase)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    135706437..135715173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039111516.2 → XP_038967444.1  E3 ubiquitin-protein ligase HECTD3 isoform X1

    Conserved Domains (2) summary
    cd08666
    Location:238 → 371
    APC10-HECTD3; APC10-like DOC1 domain of HECTD3, a HECT E3 ubiquitin ligase protein that mediates substrate ubiquitination
    cl27008
    Location:579 → 646
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

  2. XM_039111517.2 → XP_038967445.1  E3 ubiquitin-protein ligase HECTD3 isoform X2

    Conserved Domains (2) summary
    cl02148
    Location:1 → 66
    APC10-like; APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination
    pfam00632
    Location:281 → 540
    HECT; HECT-domain (ubiquitin-transferase)

RNA

  1. XR_592703.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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