Heyl hes-related family bHLH transcription factor with YRPW motif-like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Heylprovided by RGD
Official Full Name: hes-related family bHLH transcription factor with YRPW motif-likeprovided by RGD
Primary source: RGD:1305022
See related: Ensembl:ENSRNOG00000015318 AllianceGenome:RGD:1305022
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including AF-1 domain binding activity; DNA-binding transcription factor activity, RNA polymerase II-specific; and protein homodimerization activity. Predicted to be involved in several processes, including heart development; negative regulation of androgen receptor signaling pathway; and regulation of transcription, DNA-templated. Predicted to act upstream of or within animal organ development; cellular response to BMP stimulus; and negative regulation of gene expression. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Orthologous to human HEYL (hes related family bHLH transcription factor with YRPW motif like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 60.7), Muscle (RPKM 22.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (140793271..140810262)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (135508160..135525152)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (140923914..140940905)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BG378118 (e-PCR)
- UniSTS:245052

D4Mit11 (e-PCR), detects polymorphism
- UniSTS:129884

D4MIT11 (e-PCR)
- UniSTS:120441

RH143336 (e-PCR)
- UniSTS:232583

RH143142 (e-PCR)
- UniSTS:232389

BE100438 (e-PCR)
- UniSTS:249813

RH137535 (e-PCR)
- UniSTS:219623

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables AF-1 domain binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in anterior/posterior pattern specification	IBA Inferred from Biological aspect of Ancestor more info
involved_in atrioventricular valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cardiac epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in cardiac ventricle morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cellular response to BMP stimulus	ISO Inferred from Sequence Orthology more info
involved_in circulatory system development	IBA Inferred from Biological aspect of Ancestor more info
involved_in endocardial cushion morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epithelial to mesenchymal transition involved in endocardial cushion formation	ISO Inferred from Sequence Orthology more info
involved_in glomerulus development	ISO Inferred from Sequence Orthology more info
involved_in mesenchymal cell development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of androgen receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in proximal tubule development	ISO Inferred from Sequence Orthology more info
involved_in pulmonary valve morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skeletal muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in ventricular septum morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: hairy/enhancer-of-split related with YRPW motif-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107977.1 → NP_001101447.1 hairy/enhancer-of-split related with YRPW motif-like protein

See identical proteins and their annotated locations for NP_001101447.1

Status: PROVISIONAL

Source sequence(s)

CH473968

UniProtKB/TrEMBL

A6IS23, D3ZIH3

Related

ENSRNOP00000020928.2, ENSRNOT00000020929.4

Conserved Domains (2) summary

smart00511
Location:115 → 162

ORANGE; Orange domain

cd11447
Location:36 → 109

bHLH-O_HEYL; basic helix-loop-helix-orange (bHLH-O) domain found in hairy/enhancer-of-split related with YRPW motif-like protein (HEYL) and similar proteins