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Mfap2 microfibril associated protein 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313662, updated on 13-Apr-2024

Summary

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Official Symbol
Mfap2provided by RGD
Official Full Name
microfibril associated protein 2provided by RGD
Primary source
RGD:1306031
See related
Ensembl:ENSRNOG00000008257 AllianceGenome:RGD:1306031
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable fibrinogen binding activity and fibronectin binding activity. Predicted to be involved in embryonic eye morphogenesis; positive regulation of cold-induced thermogenesis; and post-embryonic eye morphogenesis. Predicted to act upstream of or within platelet formation. Predicted to be located in extracellular region. Predicted to be active in microfibril. Orthologous to human MFAP2 (microfibril associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Uterus (RPKM 80.2), Lung (RPKM 71.6) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mfap2 in Genome Data Viewer
Location:
5q36
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (158595121..158603283)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (153312068..153320266)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (159534202..159539750)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene peptidyl arginine deiminase 2 Neighboring gene succinate dehydrogenase complex iron sulfur subunit B Neighboring gene ATPase cation transporting 13A2 Neighboring gene uncharacterized LOC120103023 Neighboring gene ciliary rootlet coiled-coil, rootletin Neighboring gene NECAP endocytosis associated 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Investigation of age-related decline of microfibril-associated glycoprotein-1 in human skin through immunohistochemistry study. Zheng Q, et al. Clin Cosmet Investig Dermatol, 2013. PMID 24353434, Free PMC Article
  2. The extracellular matrix protein MAGP1 supports thermogenesis and protects against obesity and diabetes through regulation of TGF-β. Craft CS, et al. Diabetes, 2014 Jun. PMID 24458361, Free PMC Article
  3. Mice lacking the extracellular matrix protein MAGP1 display delayed thrombotic occlusion following vessel injury. Werneck CC, et al. Blood, 2008 Apr 15. PMID 18281502, Free PMC Article
  4. Human eye development is characterized by coordinated expression of fibrillin isoforms. Hubmacher D, et al. Invest Ophthalmol Vis Sci, 2014 Nov 18. PMID 25406291, Free PMC Article
  5. Disruption of murine Adamtsl4 results in zonular fiber detachment from the lens and in retinal pigment epithelium dedifferentiation. Collin GB, et al. Hum Mol Genet, 2015 Dec 15. PMID 26405179, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables fibrinogen binding ISO
Inferred from Sequence Orthology
more info
  
enables fibronectin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in embryonic eye morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in embryonic eye morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within platelet formation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cold-induced thermogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in post-embryonic eye morphogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in microfibril IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microfibril ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
microfibrillar-associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107989.2 → NP_001101459.2  microfibrillar-associated protein 2 precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    Related
    ENSRNOP00000010993.5, ENSRNOT00000010993.6

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    158595121..158603283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039110070.2 → XP_038965998.1  microfibrillar-associated protein 2 isoform X1

    Conserved Domains (1) summary
    pfam05507
    Location:135 → 216
    MAGP; Microfibril-associated glycoprotein (MAGP)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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