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Zbtb17 zinc finger and BTB domain containing 17 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313666, updated on 3-Apr-2024

Summary

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Official Symbol
Zbtb17provided by RGD
Official Full Name
zinc finger and BTB domain containing 17provided by RGD
Primary source
RGD:1307143
See related
Ensembl:ENSRNOG00000010436 AllianceGenome:RGD:1307143
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Zfp100
Summary
Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; transcription cis-regulatory region binding activity; and transcription coactivator binding activity. Predicted to be involved in negative regulation of cell population proliferation; positive regulation of transcription by RNA polymerase II; and regulation of cell cycle. Predicted to act upstream of or within ectoderm development; gastrulation with mouth forming second; and positive regulation of transcription, DNA-templated. Predicted to be located in nucleus. Predicted to be part of protein-DNA complex. Predicted to be active in nucleoplasm. Orthologous to human ZBTB17 (zinc finger and BTB domain containing 17). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 94.0), Muscle (RPKM 66.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q36
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (159036482..159057580)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (153753508..153774613)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (159993799..160014899)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene transfer RNA proline (anticodon AGG) 71 Neighboring gene heat shock protein family B (small) member 7 Neighboring gene steroid receptor associated and regulated protein Neighboring gene spen family transcriptional repressor Neighboring gene filamin binding LIM protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. An alternative pathway for gene regulation by Myc. Peukert K, et al. EMBO J, 1997 Sep 15. PMID 9312026, Free PMC Article
  2. Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1. Piluso D, et al. J Biol Chem, 2002 Nov 29. PMID 12244100
  3. Innate immunity to intraphagosomal pathogens is mediated by interferon regulatory factor 8 (IRF-8) that stimulates the expression of macrophage-specific Nramp1 through antagonizing repression by c-Myc. Alter-Koltunoff M, et al. J Biol Chem, 2008 Feb 1. PMID 18045875
  4. Miz1 is required for early embryonic development during gastrulation. Adhikary S, et al. Mol Cell Biol, 2003 Nov. PMID 14560010, Free PMC Article
  5. A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth. Wanzel M, et al. Nat Cell Biol, 2008 Sep. PMID 19160485

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables core promoter sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_negative_effect G1 to G0 transition ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ectoderm development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within gastrulation with mouth forming second ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-DNA complex ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 17
Names
zinc finger protein 100

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012105.1 → NP_001012105.1  zinc finger and BTB domain-containing protein 17

    See identical proteins and their annotated locations for NP_001012105.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083577
    UniProtKB/TrEMBL
    Q5XIU3
    Conserved Domains (7) summary
    smart00225
    Location:25 → 109
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:304 → 635
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:474 → 494
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:614 → 633
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:304 → 326
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:14 → 109
    BTB; BTB/POZ domain
    pfam13465
    Location:318 → 342
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    159036482..159057580
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287815.1 → XP_063143885.1  zinc finger and BTB domain-containing protein 17 isoform X1

    UniProtKB/TrEMBL
    F7FQA4

  2. XM_063287819.1 → XP_063143889.1  zinc finger and BTB domain-containing protein 17 isoform X2

    UniProtKB/TrEMBL
    A6ITU0

  3. XM_063287816.1 → XP_063143886.1  zinc finger and BTB domain-containing protein 17 isoform X2

    UniProtKB/TrEMBL
    A6ITU0

  4. XM_063287818.1 → XP_063143888.1  zinc finger and BTB domain-containing protein 17 isoform X2

    UniProtKB/TrEMBL
    A6ITU0

  5. XM_039110080.2 → XP_038966008.1  zinc finger and BTB domain-containing protein 17 isoform X1

    UniProtKB/TrEMBL
    F7FQA4
    Conserved Domains (4) summary
    COG5048
    Location:322 → 653
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:492 → 512
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:632 → 651
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18206
    Location:2 → 113
    BTB_POZ_ZBTB17_MIZ1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17)

  6. XM_063287817.1 → XP_063143887.1  zinc finger and BTB domain-containing protein 17 isoform X2

    UniProtKB/TrEMBL
    A6ITU0

  7. XM_039110079.2 → XP_038966007.1  zinc finger and BTB domain-containing protein 17 isoform X1

    UniProtKB/TrEMBL
    F7FQA4
    Related
    ENSRNOP00000014399.5
    Conserved Domains (4) summary
    COG5048
    Location:322 → 653
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:492 → 512
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:632 → 651
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18206
    Location:2 → 113
    BTB_POZ_ZBTB17_MIZ1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 17 (ZBTB17)

  8. XM_006239303.2 → XP_006239365.1  zinc finger and BTB domain-containing protein 17 isoform X2

    See identical proteins and their annotated locations for XP_006239365.1

    UniProtKB/TrEMBL
    A6ITU0
    Conserved Domains (7) summary
    smart00225
    Location:25 → 109
    BTB; Broad-Complex, Tramtrack and Bric a brac
    COG5048
    Location:297 → 628
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:467 → 487
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:607 → 626
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:297 → 319
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:14 → 109
    BTB; BTB/POZ domain
    pfam13465
    Location:311 → 335
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
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