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Nol9 nucleolar protein 9 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313744, updated on 11-Apr-2024

Summary

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Official Symbol
Nol9provided by RGD
Official Full Name
nucleolar protein 9provided by RGD
Primary source
RGD:1566167
See related
Ensembl:ENSRNOG00000010109 AllianceGenome:RGD:1566167
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable polynucleotide 5'-hydroxyl-kinase activity. Predicted to be involved in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in intermediate filament cytoskeleton and nucleolus. Predicted to be active in nucleus. Orthologous to human NOL9 (nucleolar protein 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 67.7), Spleen (RPKM 66.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Nol9 in Genome Data Viewer
Location:
5q36
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (167829249..167849364)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (162546522..162566625)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (169213076..169233173)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 48 Neighboring gene taste 1 receptor member 1 Neighboring gene pleckstrin homology and RhoGEF domain containing G5 Neighboring gene TNF receptor superfamily member 25

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Nol9 is a novel polynucleotide 5'-kinase involved in ribosomal RNA processing. Heindl K, et al. EMBO J, 2010 Dec 15. PMID 21063389, Free PMC Article
  2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables polynucleotide 5'-hydroxyl-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in maturation of 5.8S rRNA ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in intermediate filament cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in intermediate filament cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
polynucleotide 5'-hydroxyl-kinase NOL9
NP_001386164.1
XP_038967289.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001399235.1 → NP_001386164.1  polynucleotide 5'-hydroxyl-kinase NOL9

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6IUG5
    Related
    ENSRNOP00000013535.5, ENSRNOT00000013535.6
    Conserved Domains (1) summary
    pfam16575
    Location:322 → 482
    CLP1_P; mRNA cleavage and polyadenylation factor CLP1 P-loop

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    167829249..167849364
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039111361.2 → XP_038967289.1  polynucleotide 5'-hydroxyl-kinase NOL9 isoform X1

    UniProtKB/TrEMBL
    A0A8I5YBW7, G3V7B0
    Related
    ENSRNOP00000076785.1
    Conserved Domains (1) summary
    pfam16575
    Location:323 → 483
    CLP1_P; mRNA cleavage and polyadenylation factor CLP1 P-loop

RNA

  1. XR_005505136.2 RNA Sequence

  2. XR_005505135.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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