Zfp513 zinc finger protein 513 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zfp513provided by RGD
Official Full Name: zinc finger protein 513provided by RGD
Primary source: RGD:1310456
See related: Ensembl:ENSRNOG00000005298 AllianceGenome:RGD:1310456
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Znf513
Summary: Predicted to enable transcription cis-regulatory region binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II and retina development in camera-type eye. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in retinitis pigmentosa 58. Orthologous to human ZNF513 (zinc finger protein 513). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 49.5), Thymus (RPKM 48.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q14

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (30894153..30897414)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (25174181..25177442)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (26537707..26541051)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

Ppm1g (e-PCR), detects polymorphism
- UniSTS:143109

BF413660 (e-PCR)
- UniSTS:248582

AW990386 (e-PCR)
- UniSTS:185618

G54114 (e-PCR)
- UniSTS:109351

RH127465 (e-PCR)
- UniSTS:210775

PPM1G_7857 (e-PCR)
- UniSTS:471724

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transcription cis-regulatory region binding	IBA Inferred from Biological aspect of Ancestor more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in retina development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in retina development in camera-type eye	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: zinc finger protein 513

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001012110.2 → NP_001012110.1 zinc finger protein 513

See identical proteins and their annotated locations for NP_001012110.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q5FWU5

UniProtKB/TrEMBL

A0A8I6A7V7

Related

ENSRNOP00000040002.3, ENSRNOT00000050102.4

Conserved Domains (3) summary

COG5048
Location:414 → 487

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:152 → 172

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam13465
Location:402 → 425

zf-H2C2_2; Zinc-finger double domain