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Grhl1 grainyhead-like transcription factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313993, updated on 6-Jun-2024

Summary

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Symbol
Grhl1provided by RGD
Full Name
grainyhead-like transcription factor 1provided by RGD
Primary source
RGD:1305735
See related
Ensembl:ENSRNOG00000054989 AllianceGenome:RGD:1305735
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and protein homodimerization activity. Predicted to be involved in epidermis development and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within desmosome organization; establishment of skin barrier; and regulation of keratinocyte differentiation. Predicted to be located in nucleoplasm. Orthologous to human GRHL1 (grainyhead like transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 23.6), Testes (RPKM 21.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Grhl1 in Genome Data Viewer
Location:
6q16
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (46935947..46986126)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (41207325..41257516)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (43734837..43795757)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479119 Neighboring gene uncharacterized LOC134479120 Neighboring gene TATA-box binding protein associated factor, RNA polymerase I subunit B Neighboring gene RNA binding motif protein 34, pseudogene 1 Neighboring gene KLF transcription factor 11 Neighboring gene cystin 1 Neighboring gene ribonucleotide reductase regulatory subunit M2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Loss of Grainy head-like 1 is associated with disruption of the epidermal barrier and squamous cell carcinoma of the skin. Mlacki M, et al. PLoS One, 2014. PMID 24586629, Free PMC Article
  2. Structural basis of gene regulation by the Grainyhead/CP2 transcription factor family. Ming Q, et al. Nucleic Acids Res, 2018 Feb 28. PMID 29309642, Free PMC Article
  3. Perturbed desmosomal cadherin expression in grainy head-like 1-null mice. Wilanowski T, et al. EMBO J, 2008 Mar 19. PMID 18288204, Free PMC Article
  4. A highly conserved novel family of mammalian developmental transcription factors related to Drosophila grainyhead. Wilanowski T, et al. Mech Dev, 2002 Jun. PMID 12175488
  5. The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity. Boglev Y, et al. Dev Biol, 2011 Jan 15. PMID 21081122

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within desmosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in epidermis development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within establishment of skin barrier ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of keratinocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
grainyhead-like protein 1 homolog
Names
DNA methyltransferase 3A
grainyhead-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    46935947..46986126
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039113151.2 → XP_038969079.1  grainyhead-like protein 1 homolog isoform X1

    UniProtKB/TrEMBL
    A0A0G2JTY1
    Conserved Domains (1) summary
    pfam04516
    Location:235 → 440
    CP2; CP2 transcription factor

  2. XM_234006.11 → XP_234006.5  grainyhead-like protein 1 homolog isoform X1

    See identical proteins and their annotated locations for XP_234006.5

    UniProtKB/TrEMBL
    A0A0G2JTY1
    Related
    ENSRNOP00000068887.2
    Conserved Domains (1) summary
    pfam04516
    Location:235 → 440
    CP2; CP2 transcription factor

  3. XM_063262748.1 → XP_063118818.1  grainyhead-like protein 1 homolog isoform X2

    UniProtKB/TrEMBL
    A0A0G2JTY1

  4. XM_063262749.1 → XP_063118819.1  grainyhead-like protein 1 homolog isoform X3

    UniProtKB/TrEMBL
    A0A0G2JTY1

RNA

  1. XR_010052540.1 RNA Sequence

  2. XR_010052541.1 RNA Sequence

  3. XR_010052542.1 RNA Sequence

  4. XR_010052543.1 RNA Sequence

  5. XR_010052544.1 RNA Sequence

  6. XR_010052546.1 RNA Sequence

  7. XR_010052545.1 RNA Sequence

  8. XR_010052547.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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