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HLX H2.0 like homeobox [ Homo sapiens (human) ]

Gene ID: 3142, updated on 4-Jan-2025

Summary

Official Symbol
HLXprovided by HGNC
Official Full Name
H2.0 like homeoboxprovided by HGNC
Primary source
HGNC:HGNC:4978
See related
Ensembl:ENSG00000136630 MIM:142995; AllianceGenome:HGNC:4978
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HB24; HLX1
Summary
Enables sequence-specific DNA binding activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within several processes, including embryonic digestive tract morphogenesis; enteric nervous system development; and regulation of T-helper cell differentiation. Predicted to be located in chromatin. [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in bone marrow (RPKM 18.6), fat (RPKM 10.7) and 19 other tissues See more
Orthologs
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Genomic context

See HLX in Genome Data Viewer
Location:
1q41
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (220879443..220885059)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (220119233..220124841)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (221052785..221058401)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900455 Neighboring gene RNA, U6atac small nuclear 35, pseudogene Neighboring gene long intergenic non-protein coding RNA 1352 Neighboring gene HLX antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1827 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:221053510-221054118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:221064967-221065512 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:221065513-221066058 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:221067145-221067784 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:221069442-221070370 Neighboring gene uncharacterized LOC105372930 Neighboring gene uncharacterized LOC101929750 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2558 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1828

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in chromatin  
located_in nucleus  

General protein information

Preferred Names
H2.0-like homeobox protein
Names
H2.0-like homeo box-1
H2.0-like homeobox 1
homeobox protein HB24
homeobox protein HLX1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_021958.4NP_068777.1  H2.0-like homeobox protein

    See identical proteins and their annotated locations for NP_068777.1

    Status: VALIDATED

    Source sequence(s)
    BC033808, DA951303
    Consensus CDS
    CCDS1527.1
    UniProtKB/Swiss-Prot
    B2R8A8, Q14774, Q15988, Q59HE7, Q9NZ75
    UniProtKB/TrEMBL
    B3KXT6
    Related
    ENSP00000355870.5, ENST00000366903.8
    Conserved Domains (2) summary
    pfam00046
    Location:279332
    Homeobox; Homeobox domain
    cl27820
    Location:227344
    Abdominal-A; Homeobox protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    220879443..220885059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    220119233..220124841
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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