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Zfyve26 zinc finger FYVE-type containing 26 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314265, updated on 2-May-2024

Summary

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Official Symbol
Zfyve26provided by RGD
Official Full Name
zinc finger FYVE-type containing 26provided by RGD
Primary source
RGD:1307820
See related
Ensembl:ENSRNOG00000059875 AllianceGenome:RGD:1307820
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in double-strand break repair via homologous recombination and regulation of cytokinesis. Predicted to be located in cytoplasm. Predicted to be active in centrosome and midbody. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 15. Orthologous to human ZFYVE26 (zinc finger FYVE-type containing 26). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 61.5), Spleen (RPKM 60.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
6q24
Exon count:
42
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (103764864..103828520, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (98031874..98095538, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (102409235..102472962, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene androgen-dependent TFPI-regulating protein, pseudogene 1 Neighboring gene retinol dehydrogenase 12 Neighboring gene RAD51 paralog B Neighboring gene centrin 2 like 1 Neighboring gene uncharacterized LOC134479407

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A genome-scale DNA repair RNAi screen identifies SPG48 as a novel gene associated with hereditary spastic paraplegia. Słabicki M, et al. PLoS Biol, 2010 Jun 29. PMID 20613862, Free PMC Article
  2. PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody. Sagona AP, et al. Nat Cell Biol, 2010 Apr. PMID 20208530
  3. Integral and associated lysosomal membrane proteins. Schröder B, et al. Traffic, 2007 Dec. PMID 17897319
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3-phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-3-phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol-3-phosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in autophagosome organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within autophagosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in double-strand break repair via homologous recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in double-strand break repair via homologous recombination ISO
Inferred from Sequence Orthology
more info
  
involved_in lysosome organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within lysosome organization ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cytokinesis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokinesis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cytokinesis ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in early endosome IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome IEA
Inferred from Electronic Annotation
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody IEA
Inferred from Electronic Annotation
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
zinc finger FYVE domain-containing protein 26
Names
zinc finger, FYVE domain containing 26

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108038.1 → NP_001101508.1  zinc finger FYVE domain-containing protein 26

    See identical proteins and their annotated locations for NP_001101508.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473947
    UniProtKB/Swiss-Prot
    D3ZB97, D3ZBA4, D4A8G9
    UniProtKB/TrEMBL
    A0A8I5ZLS5
    Related
    ENSRNOP00000078943.1, ENSRNOT00000107207.1
    Conserved Domains (1) summary
    cd15724
    Location:1812 → 1872
    FYVE_ZFY26; FYVE domain found in FYVE domain-containing protein 26 (ZFY26 or ZFYVE26)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    103764864..103828520 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063261931.1 → XP_063118001.1  zinc finger FYVE domain-containing protein 26 isoform X3

  2. XM_039112292.2 → XP_038968220.1  zinc finger FYVE domain-containing protein 26 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZLS5
    Conserved Domains (1) summary
    cd15724
    Location:1813 → 1873
    FYVE_ZFY26; FYVE domain found in FYVE domain-containing protein 26 (ZFY26 or ZFYVE26)

  3. XM_039112291.2 → XP_038968219.1  zinc finger FYVE domain-containing protein 26 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K770, A0A8I5ZLS5
    Related
    ENSRNOP00000074087.2
    Conserved Domains (1) summary
    cd15724
    Location:1814 → 1874
    FYVE_ZFY26; FYVE domain found in FYVE domain-containing protein 26 (ZFY26 or ZFYVE26)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D4A8G9.1 GenPept UniProtKB/Swiss-Prot:D4A8G9

Gene LinkOut

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