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Entpd5 ectonucleoside triphosphate diphosphohydrolase 5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314312, updated on 30-Mar-2024

Summary

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Official Symbol
Entpd5provided by RGD
Official Full Name
ectonucleoside triphosphate diphosphohydrolase 5provided by RGD
Primary source
RGD:735219
See related
Ensembl:ENSRNOG00000033206 AllianceGenome:RGD:735219
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pcph
Summary
Predicted to enable guanosine-diphosphatase activity and uridine-diphosphatase activity. Predicted to be involved in several processes, including positive regulation of glycolytic process; protein N-linked glycosylation; and regulation of phosphatidylinositol 3-kinase signaling. Located in endoplasmic reticulum lumen. Orthologous to human ENTPD5 (ectonucleoside triphosphate diphosphohydrolase 5 (inactive)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 696.3), Adrenal (RPKM 519.9) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Entpd5 in Genome Data Viewer
Location:
6q31
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (109750210..109786376, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (104019095..104055311, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (108087677..108123811, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 410 Neighboring gene FAM161 centrosomal protein B Neighboring gene coenzyme Q6 monooxygenase Neighboring gene basal body orientation factor 1 Neighboring gene ring finger protein 113A2 Neighboring gene aldehyde dehydrogenase 6 family, member A1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Deregulated expression of the PCPH proto-oncogene in rat mammary tumors induced with 7,12-dimethylbenz[a]anthracene. Solanas M, et al. Mol Carcinog, 2002 Apr. PMID 11933075
  2. Quercetin changes purinergic enzyme activities and oxidative profile in platelets of rats with hypothyroidism. Baldissarelli J, et al. Biomed Pharmacother, 2016 Dec. PMID 27832996
  3. Bacterial expression, folding, purification and characterization of soluble NTPDase5 (CD39L4) ecto-nucleotidase. Murphy-Piedmonte DM, et al. Biochim Biophys Acta, 2005 Mar 14. PMID 15698960
  4. Biochemical characterization of CD39L4. Mulero JJ, et al. Biochemistry, 2000 Oct 24. PMID 11041857
  5. CD39-L4 is a secreted human apyrase, specific for the hydrolysis of nucleoside diphosphates. Mulero JJ, et al. J Biol Chem, 1999 Jul 16. PMID 10400613

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Quercetin decreases NTPDase, 5'-nucleotidase and adenosine deaminase activities in blood platelets of hypothyroid rats, and improves the oxidative profile to reduce platelet aggregation.
    Title: Quercetin changes purinergic enzyme activities and oxidative profile in platelets of rats with hypothyroidism.
  2. the expression of of PCPH in benign and malignant mammary tumors (PCPH)
    Title: Deregulated expression of the PCPH proto-oncogene in rat mammary tumors induced with 7,12-dimethylbenz[a]anthracene.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ADP phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables ADP phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables CDP phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables CDP phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables GDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables GDP phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables GDP phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables IDP phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables IDP phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables UDP phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables UDP phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables UDP phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables ribonucleoside triphosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_positive_effect 'de novo' post-translational protein folding ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_positive_effect 'de novo' post-translational protein folding ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in UDP catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in UDP catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_positive_effect UDP-glucose metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_positive_effect UDP-glucose metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nucleoside diphosphate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_positive_effect protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_positive_effect protein N-linked glycosylation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
NOT located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ectonucleoside triphosphate diphosphohydrolase 5
Names
GDPase ENTPD5
NTPDase 5
UDPase ENTPD5
guanosine-diphosphatase ENTPD5
uridine-diphosphatase ENTPD5
NP_955426.2
XP_006240405.1
XP_006240406.1
XP_006240407.1
XP_006240408.1
XP_017449640.1
XP_017449641.1
XP_017449642.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199394.2 → NP_955426.2  ectonucleoside triphosphate diphosphohydrolase 5 precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/Swiss-Prot
    Q6P6S9
    UniProtKB/TrEMBL
    A6JDW3
    Conserved Domains (1) summary
    cl17037
    Location:38 → 423
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    109750210..109786376 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240344.3 → XP_006240406.1  ectonucleoside triphosphate diphosphohydrolase 5 isoform X2

    See identical proteins and their annotated locations for XP_006240406.1

    UniProtKB/Swiss-Prot
    Q6P6S9
    UniProtKB/TrEMBL
    A6JDW3
    Conserved Domains (1) summary
    cl17037
    Location:38 → 423
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  2. XM_017594152.3 → XP_017449641.1  ectonucleoside triphosphate diphosphohydrolase 5 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZWS8, A6JDW0, A6JDW1
    Related
    ENSRNOP00000041026.4
    Conserved Domains (1) summary
    cl17037
    Location:63 → 448
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  3. XM_017594153.3 → XP_017449642.1  ectonucleoside triphosphate diphosphohydrolase 5 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZWS8, A6JDW0, A6JDW1
    Related
    ENSRNOP00000083944.1
    Conserved Domains (1) summary
    cl17037
    Location:63 → 448
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  4. XM_006240345.5 → XP_006240407.1  ectonucleoside triphosphate diphosphohydrolase 5 isoform X2

    See identical proteins and their annotated locations for XP_006240407.1

    UniProtKB/Swiss-Prot
    Q6P6S9
    UniProtKB/TrEMBL
    A6JDW3
    Conserved Domains (1) summary
    cl17037
    Location:38 → 423
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  5. XM_017594151.3 → XP_017449640.1  ectonucleoside triphosphate diphosphohydrolase 5 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZWS8, A6JDW0, A6JDW1
    Conserved Domains (1) summary
    cl17037
    Location:63 → 448
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  6. XM_006240343.5 → XP_006240405.1  ectonucleoside triphosphate diphosphohydrolase 5 isoform X2

    See identical proteins and their annotated locations for XP_006240405.1

    UniProtKB/Swiss-Prot
    Q6P6S9
    UniProtKB/TrEMBL
    A6JDW3
    Conserved Domains (1) summary
    cl17037
    Location:38 → 423
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

  7. XM_006240346.5 → XP_006240408.1  ectonucleoside triphosphate diphosphohydrolase 5 isoform X2

    See identical proteins and their annotated locations for XP_006240408.1

    UniProtKB/Swiss-Prot
    Q6P6S9
    UniProtKB/TrEMBL
    A6JDW3
    Conserved Domains (1) summary
    cl17037
    Location:38 → 423
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P6S9.1 GenPept UniProtKB/Swiss-Prot:Q6P6S9

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