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Mlh3 mutL homolog 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314320, updated on 5-Mar-2024

Summary

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Official Symbol
Mlh3provided by RGD
Official Full Name
mutL homolog 3provided by RGD
Primary source
RGD:1309227
See related
Ensembl:ENSRNOG00000006699 AllianceGenome:RGD:1309227
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ATP hydrolysis activity; centromeric DNA binding activity; and chromatin binding activity. Predicted to be involved in mismatch repair. Predicted to act upstream of or within cellular response to DNA damage stimulus; meiotic nuclear division; and protein localization. Predicted to be located in male germ cell nucleus and nuclear lumen. Predicted to be part of mismatch repair complex. Human ortholog(s) of this gene implicated in Lynch syndrome; colorectal cancer; endometrial cancer; and hereditary nonpolyposis colorectal cancer type 7. Orthologous to human MLH3 (mutL homolog 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 56.4), Heart (RPKM 49.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mlh3 in Genome Data Viewer
Location:
6q31
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (110612535..110649408, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (104881483..104917686, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (109059386..109095876, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene metallothionein 1, pseudogene 4 Neighboring gene eukaryotic translation initiation factor 2B subunit beta Neighboring gene acylphosphatase 1 Neighboring gene zinc finger, C2HC-type containing 1C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The polymorphisms of miRNA-binding site in MLH3 and ERCC1 were linked to the risk of colorectal cancer in a case-control study. Zhang Q, et al. Cancer Med, 2018 Apr. PMID 29516665, Free PMC Article
  2. A role for MLH3 in hereditary nonpolyposis colorectal cancer. Wu Y, et al. Nat Genet, 2001 Oct. PMID 11586295
  3. Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse. Chen PC, et al. Cancer Res, 2005 Oct 1. PMID 16204034
  4. Novel and diverse functions of the DNA mismatch repair family in mammalian meiosis and recombination. Kolas NK, et al. Cytogenet Genome Res, 2004. PMID 15467367
  5. Meiotic arrest and aneuploidy in MLH3-deficient mice. Lipkin SM, et al. Nat Genet, 2002 Aug. PMID 12091911

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent DNA damage sensor activity IEA
Inferred from Electronic Annotation
more info
  
enables centromeric DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables mismatched DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within female meiosis I ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within male meiotic nuclear division ISO
Inferred from Sequence Orthology
more info
  
involved_in mismatch repair IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mismatch repair ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within synaptonemal complex assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chiasma ISO
Inferred from Sequence Orthology
more info
  
located_in condensed chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in condensed nuclear chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in male germ cell nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of mismatch repair complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mismatch repair complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in synaptonemal complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
DNA mismatch repair protein Mlh3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108043.1 → NP_001101513.1  DNA mismatch repair protein Mlh3

    See identical proteins and their annotated locations for NP_001101513.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473982
    UniProtKB/TrEMBL
    A6JE18, A6JE19, D4ADG4
    Related
    ENSRNOP00000038334.2, ENSRNOT00000033493.4
    Conserved Domains (3) summary
    smart00853
    Location:1179 → 1359
    MutL_C; MutL C terminal dimerisation domain
    cd03486
    Location:206 → 349
    MutL_Trans_MLH3; transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain ...
    cd16926
    Location:9 → 192
    HATPase_MutL-MLH-PMS-like; Histidine kinase-like ATPase domain of DNA mismatch repair proteins Escherichia coli MutL, human MutL homologs (MLH/ PMS), and related domains

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    110612535..110649408 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240312.5 → XP_006240374.1  DNA mismatch repair protein Mlh3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6APJ9, A6JE19
    Related
    ENSRNOP00000090967.1
    Conserved Domains (4) summary
    smart00853
    Location:1147 → 1327
    MutL_C; MutL C terminal dimerisation domain
    cd03486
    Location:206 → 349
    MutL_Trans_MLH3; MutL_Trans_MLH3: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to ...
    TIGR00585
    Location:1 → 326
    mutl; DNA mismatch repair protein MutL
    pfam02518
    Location:22 → 149
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

  2. XM_006240311.5 → XP_006240373.1  DNA mismatch repair protein Mlh3 isoform X1

    UniProtKB/TrEMBL
    A6JE19
    Conserved Domains (4) summary
    smart00853
    Location:1176 → 1356
    MutL_C; MutL C terminal dimerisation domain
    cd03486
    Location:206 → 349
    MutL_Trans_MLH3; MutL_Trans_MLH3: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to ...
    TIGR00585
    Location:1 → 326
    mutl; DNA mismatch repair protein MutL
    pfam02518
    Location:22 → 149
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

  3. XM_063261941.1 → XP_063118011.1  DNA mismatch repair protein Mlh3 isoform X4

  4. XM_006240313.5 → XP_006240375.1  DNA mismatch repair protein Mlh3 isoform X3

    UniProtKB/TrEMBL
    A6JE19
    Conserved Domains (3) summary
    cd03486
    Location:206 → 349
    MutL_Trans_MLH3; MutL_Trans_MLH3: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to ...
    TIGR00585
    Location:1 → 326
    mutl; DNA mismatch repair protein MutL
    pfam02518
    Location:22 → 149
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

  5. XM_006240314.5 → XP_006240376.1  DNA mismatch repair protein Mlh3 isoform X5

    UniProtKB/TrEMBL
    A6JE19
    Conserved Domains (3) summary
    cd03486
    Location:206 → 349
    MutL_Trans_MLH3; MutL_Trans_MLH3: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to yeast and human MLH3 (MutL homologue 3). MLH3 belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to ...
    TIGR00585
    Location:1 → 326
    mutl; DNA mismatch repair protein MutL
    pfam02518
    Location:22 → 149
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Nucleotide Protein Strain
Heading Accession and Version

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