Sel1l SEL1L adaptor subunit of SYVN1 ubiquitin ligase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Sel1lprovided by RGD
Official Full Name: SEL1L adaptor subunit of SYVN1 ubiquitin ligaseprovided by RGD
Primary source: RGD:620147
See related: Ensembl:ENSRNOG00000004464 AllianceGenome:RGD:620147
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Sel1h
Summary: Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in ERAD pathway; protein secretion; and triglyceride metabolic process. Predicted to act upstream of or within response to endoplasmic reticulum stress. Predicted to be located in endoplasmic reticulum. Predicted to be part of Derlin-1 retrotranslocation complex and Hrd1p ubiquitin ligase ERAD-L complex. Human ortholog(s) of this gene implicated in pancreatic cancer. Orthologous to human SEL1L (SEL1L adaptor subunit of ERAD E3 ubiquitin ligase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 457.3), Kidney (RPKM 278.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q31

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (116466163..116510436, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (110735450..110779695, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (115572683..115616904, complement)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERAD pathway	ISO Inferred from Sequence Orthology more info
involved_in ERAD pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in biological_process	ND No biological Data available more info
involved_in protein secretion	IEA Inferred from Electronic Annotation more info
involved_in protein secretion	ISO Inferred from Sequence Orthology more info
involved_in protein secretion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within response to endoplasmic reticulum stress	ISO Inferred from Sequence Orthology more info
involved_in retrograde protein transport, ER to cytosol	IEA Inferred from Electronic Annotation more info
involved_in retrograde protein transport, ER to cytosol	ISO Inferred from Sequence Orthology more info
involved_in triglyceride metabolic process	IEA Inferred from Electronic Annotation more info
involved_in triglyceride metabolic process	ISO Inferred from Sequence Orthology more info
involved_in triglyceride metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Derlin-1 retrotranslocation complex	IEA Inferred from Electronic Annotation more info
part_of Derlin-1 retrotranslocation complex	ISO Inferred from Sequence Orthology more info
part_of Hrd1p ubiquitin ligase ERAD-L complex	IEA Inferred from Electronic Annotation more info
part_of Hrd1p ubiquitin ligase ERAD-L complex	ISO Inferred from Sequence Orthology more info
part_of Hrd1p ubiquitin ligase ERAD-L complex	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: protein sel-1 homolog 1

Names: SEL1L ERAD E3 ligase adaptor subunit; SEL1L adaptor subunit of ERAD E3 ubiquitin ligase; Sel1 (suppressor of lin-12) 1 homolog; sel-1 suppressor of lin-12-like; sel-1L; suppressor of lin-12-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_177933.5 → NP_808794.2 protein sel-1 homolog 1 precursor

See identical proteins and their annotated locations for NP_808794.2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/Swiss-Prot

Q80Z70

UniProtKB/TrEMBL

A6JED2, G3V9D3

Related

ENSRNOP00000043232.3, ENSRNOT00000045870.6

Conserved Domains (4) summary

smart00059
Location:119 → 167

FN2; Fibronectin type 2 domain

smart00671
Location:482 → 517

SEL1; Sel1-like repeats

COG0790
Location:182 → 517

TPR; TPR repeat [Signal transduction mechanisms]

sd00010
Location:392 → 421

SLR; SLR repeat [structural motif]