Rin3 Ras and Rab interactor 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rin3provided by RGD
Official Full Name: Ras and Rab interactor 3provided by RGD
Primary source: RGD:1305849
See related: Ensembl:ENSRNOG00000007062 AllianceGenome:RGD:1305849
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable guanyl-nucleotide exchange factor activity and small GTPase binding activity. Predicted to be involved in regulation of catalytic activity; signal transduction; and vesicle-mediated transport. Predicted to act upstream of or within negative regulation of receptor internalization and regulation of vesicle size. Predicted to be located in several cellular components, including cytoplasmic vesicle; dendrite; and neuronal cell body. Orthologous to human RIN3 (Ras and Rab interactor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 59.6), Thymus (RPKM 42.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q32

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (127196648..127305821)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (121431776..121540956)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (126170672..126279682)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTPase activator activity	IEA Inferred from Electronic Annotation more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of negative regulation of mast cell chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of receptor internalization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of vesicle size	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
is_active_in endocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ras and Rab interactor 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108052.2 → NP_001101522.1 ras and Rab interactor 3 isoform 3

See identical proteins and their annotated locations for NP_001101522.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A0A0G2K0G9, A0A8I6GJV5, A6JEJ9

Related

ENSRNOP00000092596.1, ENSRNOT00000098291.1

Conserved Domains (3) summary

pfam02204
Location:654 → 756

VPS9; Vacuolar sorting protein 9 (VPS9) domain

cl00155
Location:805 → 875

UBQ; Ubiquitin-like proteins

cl15255
Location:1 → 70

SH2; Src homology 2 (SH2) domain
NM_001414929.1 → NP_001401858.1 ras and Rab interactor 3 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

D3ZFZ0

Related

ENSRNOP00000062921.2, ENSRNOT00000065246.3
NM_001414930.1 → NP_001401859.1 ras and Rab interactor 3 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

Related

ENSRNOP00000071441.2, ENSRNOT00000077477.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

127196648..127305821

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039112360.2 → XP_038968288.1 ras and Rab interactor 3 isoform X1

Conserved Domains (3) summary

cd10395
Location:52 → 153

SH2_RIN3; Src homology 2 (SH2) domain found in Ras and Rab interactor 3 (RIN3)-like proteins

PHA03247
Location:244 → 562

PHA03247; large tegument protein UL36; Provisional

cl19569
Location:736 → 779

VPS9; Vacuolar sorting protein 9 (VPS9) domain
XM_063261977.1 → XP_063118047.1 ras and Rab interactor 3 isoform X2
XM_039112361.2 → XP_038968289.1 ras and Rab interactor 3 isoform X2

Conserved Domains (2) summary

cd16130
Location:545 → 632

RA_Rin3; Ras-associating (RA) domain found in Ras and Rab interactor 3 (Rin3)

pfam02204
Location:407 → 510

VPS9; Vacuolar sorting protein 9 (VPS9) domain