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Midn midnolin [ Rattus norvegicus (Norway rat) ]

Gene ID: 314623, updated on 30-Mar-2024

Summary

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Official Symbol
Midnprovided by RGD
Official Full Name
midnolinprovided by RGD
Primary source
RGD:1309629
See related
Ensembl:ENSRNOG00000015434 AllianceGenome:RGD:1309629
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables kinase binding activity. Acts upstream of or within negative regulation of glucokinase activity and negative regulation of insulin secretion. Predicted to be located in cytosol and nucleolus. Predicted to be active in nucleus. Orthologous to human MIDN (midnolin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 59.5), Thymus (RPKM 55.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Midn in Genome Data Viewer
Location:
7q11
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (10198761..10210563, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (9548100..9559605, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (12414303..12426712, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 174 member C Neighboring gene cold inducible RNA binding protein Neighboring gene ATP synthase F1 subunit delta Neighboring gene CACN subunit beta associated regulatory protein Neighboring gene serine/threonine kinase 11

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Transcriptome Analysis Reveals That Midnolin Regulates mRNA Expression Levels of Multiple Parkinson's Disease Causative Genes. Obara Y, et al. Biol Pharm Bull, 2018. PMID 29311479
  2. Novel nucleolar protein, midnolin, is expressed in the mesencephalon during mouse development. Tsukahara M, et al. Gene, 2000 Aug 22. PMID 10974535
  3. Midnolin is a novel regulator of parkin expression and is associated with Parkinson's Disease. Obara Y, et al. Sci Rep, 2017 Jul 19. PMID 28724963, Free PMC Article
  4. Identification of the ubiquitin-like domain of midnolin as a new glucokinase interaction partner. Hofmeister-Brix A, et al. J Biol Chem, 2013 Dec 13. PMID 24187134, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MIDN promotes the expression of parkin E3 ubiquitin ligase, and that MIDN loss can trigger Parkinson's disease-related pathogenic mechanisms.
    Title: Midnolin is a novel regulator of parkin expression and is associated with Parkinson's Disease.
  2. These findings indicate that MIDN regulates the expression of a wide variety of genes, including multiple Parkinson's Disease causative genes and is associated with Parkinson's Disease onset.
    Title: Transcriptome Analysis Reveals That Midnolin Regulates mRNA Expression Levels of Multiple Parkinson's Disease Causative Genes.
  3. midnolin plays a role in cellular signaling of adult tissues and regulates glucokinase enzyme activity in pancreatic beta cells
    Title: Identification of the ubiquitin-like domain of midnolin as a new glucokinase interaction partner.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of insulin secretion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in proteasomal ubiquitin-independent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
NOT located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
midnolin
Names
midbrain nucleolar protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191577.1 → NP_001178506.1  midnolin

    See identical proteins and their annotated locations for NP_001178506.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    D4AE48
    UniProtKB/TrEMBL
    A6K8Q2
    Conserved Domains (1) summary
    cd01804
    Location:32 → 101
    Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    10198761..10210563 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240913.5 → XP_006240975.1  midnolin isoform X2

    UniProtKB/TrEMBL
    A6K8Q2
    Conserved Domains (2) summary
    cd01804
    Location:31 → 108
    midnolin_N; Ubiquitin-like domain of midnolin
    smart00213
    Location:32 → 100
    UBQ; Ubiquitin homologues

  2. XM_006240911.5 → XP_006240973.1  midnolin isoform X1

    See identical proteins and their annotated locations for XP_006240973.1

    UniProtKB/Swiss-Prot
    D4AE48
    UniProtKB/TrEMBL
    A6K8Q2
    Related
    ENSRNOP00000057429.2
    Conserved Domains (1) summary
    cd01804
    Location:32 → 101
    Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins

  3. XM_017594815.3 → XP_017450304.1  midnolin isoform X4

    UniProtKB/TrEMBL
    A6K8Q1

  4. XM_006240914.5 → XP_006240976.1  midnolin isoform X3

    UniProtKB/TrEMBL
    A0A8I6A3L5, A6K8Q1
    Related
    ENSRNOP00000085295.1
    Conserved Domains (2) summary
    cd01804
    Location:31 → 108
    midnolin_N; Ubiquitin-like domain of midnolin
    smart00213
    Location:32 → 100
    UBQ; Ubiquitin homologues

  5. XM_006240912.5 → XP_006240974.1  midnolin isoform X1

    See identical proteins and their annotated locations for XP_006240974.1

    UniProtKB/Swiss-Prot
    D4AE48
    UniProtKB/TrEMBL
    A6K8Q2
    Conserved Domains (1) summary
    cd01804
    Location:32 → 101
    Ubl_midnolin; ubiquitin-like (Ubl) domain found in midnolin and similar proteins

  6. XM_008765097.4 → XP_008763319.1  midnolin isoform X5

    UniProtKB/TrEMBL
    A6K8Q2
    Conserved Domains (1) summary
    cl00155
    Location:2 → 31
    UBQ; Ubiquitin-like proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D4AE48.1 GenPept UniProtKB/Swiss-Prot:D4AE48

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