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Col14a1 collagen type XIV alpha 1 chain [ Rattus norvegicus (Norway rat) ]

Gene ID: 314981, updated on 2-May-2024

Summary

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Official Symbol
Col14a1provided by RGD
Official Full Name
collagen type XIV alpha 1 chainprovided by RGD
Primary source
RGD:1305806
See related
Ensembl:ENSRNOG00000026415 AllianceGenome:RGD:1305806
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to act upstream of or within several processes, including collagen fibril organization; homeostasis of number of cells within a tissue; and regulation of cell growth involved in cardiac muscle cell development. Predicted to be part of collagen trimer. Predicted to be active in extracellular space and interstitial matrix. Orthologous to human COL14A1 (collagen type XIV alpha 1 chain). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 339.8), Muscle (RPKM 238.1) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Col14a1 in Genome Data Viewer
Location:
7q32
Exon count:
49
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (88611827..88826939)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (86722093..86937215)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (95054877..95274073)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene DEP domain containing MTOR-interacting protein Neighboring gene U7 small nuclear RNA Neighboring gene ribosomal protein L31, pseudogene 5 Neighboring gene eukaryotic translation initiation factor 1, pseudogene 1 Neighboring gene mitochondrial ribosomal protein L13 Neighboring gene MDM2 binding protein Neighboring gene uncharacterized LOC120093658

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of a DNA methylome profile of esophageal squamous cell carcinoma and potential plasma epigenetic biomarkers for early diagnosis. Li X, et al. PLoS One, 2014. PMID 25050929, Free PMC Article
  2. Collagen XIV is important for growth and structural integrity of the myocardium. Tao G, et al. J Mol Cell Cardiol, 2012 Nov. PMID 22906538, Free PMC Article
  3. Proteomics characterization of extracellular space components in the human aorta. Didangelos A, et al. Mol Cell Proteomics, 2010 Sep. PMID 20551380, Free PMC Article
  4. Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins. Barallobre-Barreiro J, et al. Cardiovasc Res, 2016 Jun 1. PMID 27068509, Free PMC Article
  5. Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. Abonnenc M, et al. Circ Res, 2013 Oct 25. PMID 24006456

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
acts_upstream_of_or_within collagen fibril organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within homeostasis of number of cells within a tissue ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of cell growth involved in cardiac muscle cell development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ventricular cardiac muscle tissue development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in interstitial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in interstitial matrix ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
collagen alpha-1(XIV) chain
Names
collagen, type XIV, alpha 1 (undulin)
procollagen, type XIV, alpha 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130548.2 → NP_001124020.1  collagen alpha-1(XIV) chain precursor

    See identical proteins and their annotated locations for NP_001124020.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I6AK67, A6HRH1
    Related
    ENSRNOP00000093489.1, ENSRNOT00000094987.1
    Conserved Domains (7) summary
    smart00060
    Location:448 → 517
    FN3; Fibronectin type 3 domain
    smart00210
    Location:1227 → 1422
    TSPN; Thrombospondin N-terminal -like domains
    cd00063
    Location:538 → 622
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd01482
    Location:1029 → 1193
    vWA_collagen_alphaI-XII-like; Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different ...
    pfam00041
    Location:830 → 906
    fn3; Fibronectin type III domain
    pfam01391
    Location:1478 → 1602
    Collagen; Collagen triple helix repeat (20 copies)
    cl21522
    Location:920 → 995
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    88611827..88826939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079204.1 → XP_038935132.1  collagen alpha-1(XIV) chain isoform X1

    UniProtKB/TrEMBL
    A0A8I6AK67, A6HRH1
    Conserved Domains (7) summary
    smart00060
    Location:448 → 517
    FN3; Fibronectin type 3 domain
    smart00210
    Location:1227 → 1422
    TSPN; Thrombospondin N-terminal -like domains
    cd00063
    Location:538 → 622
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd01482
    Location:1029 → 1193
    vWA_collagen_alphaI-XII-like; Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different ...
    pfam00041
    Location:830 → 906
    fn3; Fibronectin type III domain
    pfam01391
    Location:1478 → 1602
    Collagen; Collagen triple helix repeat (20 copies)
    cl21522
    Location:920 → 995
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

  2. XM_039079205.1 → XP_038935133.1  collagen alpha-1(XIV) chain isoform X2

    UniProtKB/TrEMBL
    A0A8I6AK67, D3ZZT9
    Related
    ENSRNOP00000063778.4, ENSRNOT00000067649.4
    Conserved Domains (7) summary
    smart00060
    Location:448 → 517
    FN3; Fibronectin type 3 domain
    smart00210
    Location:1227 → 1422
    TSPN; Thrombospondin N-terminal -like domains
    cd00063
    Location:538 → 622
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd01482
    Location:1029 → 1193
    vWA_collagen_alphaI-XII-like; Collagen: The extracellular matrix represents a complex alloy of variable members of diverse protein families defining structural integrity and various physiological functions. The most abundant family is the collagens with more than 20 different ...
    pfam00041
    Location:830 → 906
    fn3; Fibronectin type III domain
    pfam01391
    Location:1478 → 1602
    Collagen; Collagen triple helix repeat (20 copies)
    cl21522
    Location:920 → 995
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
Nucleotide Protein Strain
Heading Accession and Version

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