Upk3a uroplakin 3A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Upk3aprovided by RGD
Official Full Name: uroplakin 3Aprovided by RGD
Primary source: RGD:1310633
See related: Ensembl:ENSRNOG00000013593 AllianceGenome:RGD:1310633
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in epithelial cell differentiation; urea transport; and water transport. Predicted to act upstream of or within cell morphogenesis; monovalent inorganic cation homeostasis; and urogenital system development. Predicted to be located in apical plasma membrane urothelial plaque. Predicted to be active in plasma membrane. Predicted to be integral component of membrane. Orthologous to human UPK3A (uroplakin 3A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 18.8), Lung (RPKM 1.8) and 1 other tissue See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (118008898..118019865)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (116128981..116139950)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (125920357..125925430)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

During urothelial carcinogenesis, UPII expression was the most decreased in all urothelial lesions, while UPIa, UPIb, and UPIIIa expression was differently altered in different types of lesions
Title: Altered expression of UPIa, UPIb, UPII, and UPIIIa during urothelial carcinogenesis induced by N-butyl-N-(4-hydroxybutyl)nitrosamine in rats.

Submit: New GeneRIF Correction

General gene information

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Markers

Upk3a (e-PCR), detects polymorphism
- UniSTS:496534

Upk3a (e-PCR), detects polymorphism
- UniSTS:527019

Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within kidney development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within potassium ion homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sodium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in urea transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within urea transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within urinary bladder development	ISO Inferred from Sequence Orthology more info
involved_in water transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within water transport	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in apical plasma membrane urothelial plaque	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: uroplakin-3a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.