Act5C Actin 5C [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Act5Cprovided by FlyBase
Official Full Name: Actin 5Cprovided by FlyBase
Primary source: FLYBASE:FBgn0000042
Locus tag: Dmel_CG4027
See related: AllianceGenome:FB:FBgn0000042
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: A; A4V404_DROME; Ac5C; act; Act; ACT; act 5C; Act-5C; ACT1_DROME; Act5; act5C; Act5c; ACT5C; actin; Actin; Actin/BAP47; actin5C; Actin5C; actomyosin; anon-EST:fe2D2; ArpA; Bap47; BAP47; beta-actin; beta-Actin; beta-actin/Bap47; CG4027; chrX:5748184..5748304; cyt5C; Dmel\CG4027; f-actin; F-actin; F-Actin; F-ACTIN; G-actin; l(1)G0009; l(1)G0010; l(1)G0025; l(1)G0079; l(1)G0117; l(1)G0177; l(1)G0245; l(1)G0330; l(1)G0420; l(1)G0486; M32055; T11
Summary: Involved in several processes, including maintenance of protein location in cell; mitotic cytokinesis; and sperm individualization. Part of Ino80 complex and brahma complex. Is expressed in several structures, including circulatory system; embryonic/larval midgut; ganglia; gonad; and presumptive embryonic/larval system. Human ortholog(s) of this gene implicated in Baraitser-Winter syndrome and autosomal dominant nonsyndromic deafness 20. Orthologous to human ACTB (actin beta) and ACTG1 (actin gamma 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 5C7-5C7; 1-14 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (5900861..5905399)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (5794894..5799432)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The fat body cortical actin network regulates Drosophila inter-organ nutrient trafficking, signaling, and adipose cell size.
Title: The fat body cortical actin network regulates Drosophila inter-organ nutrient trafficking, signaling, and adipose cell size.
Lysine acetylation of F-actin decreases tropomyosin-based inhibition of actomyosin activity.
Title: Lysine acetylation of F-actin decreases tropomyosin-based inhibition of actomyosin activity.
Persistent and polarized global actin flow is essential for directionality during cell migration.
Title: Persistent and polarized global actin flow is essential for directionality during cell migration.
The disruption of DNlg1, DNlg2, or their presynaptic partner neurexin (DNrx) led to a dramatic decrease in the amount of F-actin. Further study showed that DNlg1, but not DNlg2 or DNlg3, directly interacts with the WRC via its C-terminal interacting receptor sequence.
Title: Neurexin-Neuroligin 1 regulates synaptic morphology and functions via the WAVE regulatory complex in Drosophila neuromuscular junction.
These findings revise the existing spermiation model in Drosophila and suggest that somatic cells can actively oppose mechanical cell invasion attempts using calibrated F-actin dynamics in situ
Title: Localized, Reactive F-Actin Dynamics Prevents Abnormal Somatic Cell Penetration by Mature Spermatids.
Data suggest that the molecular and structural mechanism of actin polymerization by Spire should apply to other actin-binding proteins that contain WH2 domains in tandem.
Title: Molecular architecture of the Spire-actin nucleus and its implication for actin filament assembly.
actin filament subunits were directly modified by Mical on their conserved pointed-end, critical for filament assembly; Mical posttranslationally oxidized the methionine 44 residue within D-loop of actin, severing filaments and decreasing polymerization
Title: Direct redox regulation of F-actin assembly and disassembly by Mical.
essential cytoplasmic actin isoform
Title: One of the two cytoplasmic actin isoforms in Drosophila is essential.
A mutational strategy is used to express monomeric 5C actin that is incapable of polymerization, able to bind skeletal myosin subfragment 1 and form a homogeneous complex, an ideal candidate for structural studies of actin complexes with motor proteins.
Title: Expression of a nonpolymerizable actin mutant in Sf9 cells.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fb23d02.x1 (e-PCR)
- UniSTS:190320

PMC356969P12 (e-PCR)
- UniSTS:273274

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IC Inferred by Curator more info	PubMed
involved_in maintenance of protein location in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sperm individualization	IEP Inferred from Expression Pattern more info	PubMed
involved_in tube formation	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of Ino80 complex	IDA Inferred from Direct Assay more info	PubMed
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
part_of brahma complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: actin 5C

Names: 5C actin; Act5C-PA; Act5C-PB; Act5C-PC; Act5C-PD; Act5C-PE; CG4027-PA; CG4027-PB; CG4027-PC; CG4027-PD; CG4027-PE; Dm-actin5C; F-actin; G-actin; actin; actin 5 C; actin 5c; actin A1; actin5C; anon-fast-evolving-2D2; beta-actin; cellular cytoskeletal beta-actin