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Alg12 ALG12, alpha-1,6-mannosyltransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 315212, updated on 2-May-2024

Summary

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Official Symbol
Alg12provided by RGD
Official Full Name
ALG12, alpha-1,6-mannosyltransferaseprovided by RGD
Primary source
RGD:1304826
See related
Ensembl:ENSRNOG00000004591 AllianceGenome:RGD:1304826
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable alpha-1,6-mannosyltransferase activity. Predicted to be involved in protein N-linked glycosylation. Predicted to act upstream of or within dolichol-linked oligosaccharide biosynthetic process. Predicted to be located in endoplasmic reticulum lumen. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation Ig. Orthologous to human ALG12 (ALG12 alpha-1,6-mannosyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 59.8), Kidney (RPKM 59.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Alg12 in Genome Data Viewer
Location:
7q34
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (121774796..121789175, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (119895112..119909488, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (129798663..129812677, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547254 Neighboring gene zinc finger, BED-type containing 4 Neighboring gene cysteine-rich with EGF-like domains 2 Neighboring gene transfer RNA leucine (anticodon AAG) 11 Neighboring gene Pim-3 proto-oncogene, serine/threonine kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Congenital disorders of glycosylation type Ig is defined by a deficiency in dolichyl-P-mannose:Man7GlcNAc2-PP-dolichyl mannosyltransferase. Chantret I, et al. J Biol Chem, 2002 Jul 12. PMID 11983712
  2. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alpha-1,6-mannosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase IEA
Inferred from Electronic Annotation
more info
  
enables dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within dolichol-linked oligosaccharide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in dolichol-linked oligosaccharide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein N-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase
Names
alpha-1,6-mannosyltransferase ALG12
asparagine-linked glycosylation 12 homolog (yeast, alpha-1,6-mannosyltransferase)
asparagine-linked glycosylation 12, alpha-1,6-mannosyltransferase
NP_001101574.2
XP_017450363.1
XP_017450364.1
XP_017450365.1
XP_017450366.1
XP_038935231.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108104.2 → NP_001101574.2  dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase precursor

    See identical proteins and their annotated locations for NP_001101574.2

    Status: VALIDATED

    Source sequence(s)
    BC161934, BF409974, FM050024
    UniProtKB/TrEMBL
    B1WBY3
    Related
    ENSRNOP00000061731.1, ENSRNOT00000065848.2
    Conserved Domains (1) summary
    cl21590
    Location:17 → 405
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    121774796..121789175 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594876.3 → XP_017450365.1  dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase isoform X1

    UniProtKB/TrEMBL
    B1WBY3
    Conserved Domains (1) summary
    cl21590
    Location:17 → 405
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

  2. XM_017594874.3 → XP_017450363.1  dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase isoform X1

    UniProtKB/TrEMBL
    B1WBY3
    Conserved Domains (1) summary
    cl21590
    Location:17 → 405
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

  3. XM_017594877.3 → XP_017450366.1  dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase isoform X1

    UniProtKB/TrEMBL
    B1WBY3
    Conserved Domains (1) summary
    cl21590
    Location:17 → 405
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

  4. XM_017594875.3 → XP_017450364.1  dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase isoform X1

    UniProtKB/TrEMBL
    B1WBY3
    Conserved Domains (1) summary
    cl21590
    Location:17 → 405
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase

  5. XM_039079303.2 → XP_038935231.1  dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase isoform X1

    UniProtKB/TrEMBL
    B1WBY3
    Conserved Domains (1) summary
    cl21590
    Location:17 → 405
    PMT_2; Dolichyl-phosphate-mannose-protein mannosyltransferase
Nucleotide Protein Strain
Heading Accession and Version

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