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Shmt Serine hydroxymethyl transferase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31524, updated on 26-Apr-2024

Summary

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Official Symbol
Shmtprovided by FlyBase
Official Full Name
Serine hydroxymethyl transferaseprovided by FlyBase
Primary source
FLYBASE:FBgn0029823
Locus tag
Dmel_CG3011
See related
AllianceGenome:FB:FBgn0029823
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
144561_at; anon-WO03040301.100; CG3011; Dmel\CG3011; HTMLA; Q9W457; shmt; SHMT; Shmt2
Summary
Enables glycine hydroxymethyltransferase activity. Involved in several processes, including behavioral response to ethanol; glycine biosynthetic process from serine; and tetrahydrofolate metabolic process. Located in cytoplasm and nucleus. Is expressed in several structures, including adult heart; embryonic/larval fat body; embryonic/larval midgut; germ layer derivative; and yolk nucleus. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to several human genes including SHMT1 (serine hydroxymethyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
5C7-5C7; 1-14 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5913067..5916797, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5807100..5810830, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Actin 5C Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR44108 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Essential Function of the Serine Hydroxymethyl Transferase (SHMT) Gene During Rapid Syncytial Cell Cycles in Drosophila. Winkler F, et al. G3 (Bethesda), 2017 Jul 5. PMID 28515048, Free PMC Article
  2. Chemical Embryology Redux: Metabolic Control of Development. Song Y, et al. Trends Genet, 2020 Aug. PMID 32532533, Free PMC Article
  3. D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep. Dai X, et al. Nat Commun, 2019 May 7. PMID 31064979, Free PMC Article
  4. dATF4 regulation of mitochondrial folate-mediated one-carbon metabolism is neuroprotective. Celardo I, et al. Cell Death Differ, 2017 Apr. PMID 28211874, Free PMC Article
  5. A Link between Deoxyribonucleotide Metabolites and Embryonic Cell-Cycle Control. Liu B, et al. Curr Biol, 2019 Apr 1. PMID 30880011

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A gene-nutrient interaction between vitamin B6 and serine hydroxymethyltransferase (SHMT) affects genome integrity in Drosophila.
    Title: A gene-nutrient interaction between vitamin B6 and serine hydroxymethyltransferase (SHMT) affects genome integrity in Drosophila.
  2. data suggest that mutant eggs contain maternally-provided and SHMT-dependent metabolites in amounts that suffice for early development until interphase 13.
    Title: Essential Function of the Serine Hydroxymethyl Transferase (SHMT) Gene During Rapid Syncytial Cell Cycles in Drosophila.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables glycine hydroxymethyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycine hydroxymethyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables glycine hydroxymethyltransferase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in behavioral response to ethanol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycine biosynthetic process from serine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycine biosynthetic process from serine IEA
Inferred from Electronic Annotation
more info
  
involved_in glycine biosynthetic process from serine IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of circadian rhythm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in tetrahydrofolate interconversion IEA
Inferred from Electronic Annotation
more info
  
involved_in tetrahydrofolate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tetrahydrofolate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
serine hydroxymethyl transferase
Names
CG3011-PA
CG3011-PB
CG3011-PC
Shmt-PA
Shmt-PB
Shmt-PC
beta-hydroxy-Epsilon-N-trimethyllysine aldolase
glycine hydroxylmethyltransferase
serine hydroxymethyl transferase 2
serine hydroxymethyltransferase
serine hydroxymethyltransferase 2
NP_001138162.1
NP_001284916.1
NP_572278.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    5913067..5916797 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132050.2 → NP_572278.1  serine hydroxymethyl transferase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572278.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W457
    Related
    FBpp0070792
    Conserved Domains (2) summary
    cd00378
    Location:82 → 493
    SHMT; Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl ...
    PLN03226
    Location:79 → 536
    PLN03226; serine hydroxymethyltransferase; Provisional

  2. NM_001297987.1 → NP_001284916.1  serine hydroxymethyl transferase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284916.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z0X1
    Conserved Domains (2) summary
    cd00378
    Location:12 → 423
    SHMT; Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl ...
    PLN03226
    Location:9 → 466
    PLN03226; serine hydroxymethyltransferase; Provisional

  3. NM_001144690.2 → NP_001138162.1  serine hydroxymethyl transferase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001138162.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B7Z0X1
    Conserved Domains (2) summary
    cd00378
    Location:12 → 423
    SHMT; Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl ...
    PLN03226
    Location:9 → 466
    PLN03226; serine hydroxymethyltransferase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B7Z0X1 B7Z0X1
Q9W457 Q9W457

Gene LinkOut

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