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Tfcp2 transcription factor CP2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315309, updated on 13-Apr-2024

Summary

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Official Symbol
Tfcp2provided by RGD
Official Full Name
transcription factor CP2provided by RGD
Primary source
RGD:1306738
See related
Ensembl:ENSRNOG00000032395 AllianceGenome:RGD:1306738
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tcfcp2
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein C-terminus binding activity. Predicted to be involved in mRNA transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Orthologous to human TFCP2 (transcription factor CP2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 96.7), Adrenal (RPKM 92.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tfcp2 in Genome Data Viewer
Location:
7q36
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (133495577..133537799, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (131616777..131658995, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (142138836..142181036, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 11 member 2 Neighboring gene uncharacterized LOC120093735 Neighboring gene LETM1 domain containing 1 Neighboring gene cysteine and serine rich nuclear protein 2 Neighboring gene uncharacterized LOC120093736 Neighboring gene POU class 6 homeobox 1 Neighboring gene uncharacterized LOC134479579

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Transcription factor CP2 is involved in activating mBMP4 in mouse mesenchymal stem cells. Kang HC, et al. Mol Cells, 2004 Jun 30. PMID 15232220
  2. Induction of human fetal globin gene expression by a novel erythroid factor, NF-E4. Zhou W, et al. Mol Cell Biol, 2000 Oct. PMID 11003662, Free PMC Article
  3. The Fe65 adaptor protein interacts through its PID1 domain with the transcription factor CP2/LSF/LBP1. Zambrano N, et al. J Biol Chem, 1998 Aug 7. PMID 9685356
  4. PHB2 interacts with RNF2 and represses CP2c-stimulated transcription. Lee SJ, et al. Mol Cell Biochem, 2008 Dec. PMID 18629613
  5. Repression of human gamma-globin gene expression by a short isoform of the NF-E4 protein is associated with loss of NF-E2 and RNA polymerase II recruitment to the promoter. Zhao Q, et al. Blood, 2006 Mar 1. PMID 16263792, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC187831

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in mRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
alpha-globin transcription factor CP2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134714.2 → NP_001128186.1  alpha-globin transcription factor CP2

    See identical proteins and their annotated locations for NP_001128186.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/TrEMBL
    A0A8I6AB07, B4F788, G3V969
    Related
    ENSRNOP00000037251.5, ENSRNOT00000037447.7
    Conserved Domains (2) summary
    cd09589
    Location:329 → 395
    SAM_TFCP2; SAM domain of TFCP2 transcription factors
    pfam04516
    Location:52 → 259
    CP2; CP2 transcription factor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    133495577..133537799 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242341.5 → XP_006242403.1  alpha-globin transcription factor CP2 isoform X1

    See identical proteins and their annotated locations for XP_006242403.1

    UniProtKB/TrEMBL
    A0A0G2JTJ9, A0A8I6AB07, A6KCK2
    Related
    ENSRNOP00000068740.1
    Conserved Domains (2) summary
    cd09589
    Location:329 → 395
    SAM_TFCP2; SAM domain of TFCP2 transcription factors
    pfam04516
    Location:52 → 259
    CP2; CP2 transcription factor

  2. XM_017594896.3 → XP_017450385.1  alpha-globin transcription factor CP2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AB07, B4F788, G3V969
    Conserved Domains (2) summary
    cd09589
    Location:329 → 395
    SAM_TFCP2; SAM domain of TFCP2 transcription factors
    pfam04516
    Location:52 → 259
    CP2; CP2 transcription factor

  3. XM_017594895.3 → XP_017450384.1  alpha-globin transcription factor CP2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2JTJ9, A0A8I6AB07, A6KCK2
    Related
    ENSRNOP00000091135.1
    Conserved Domains (2) summary
    cd09589
    Location:329 → 395
    SAM_TFCP2; SAM domain of TFCP2 transcription factors
    pfam04516
    Location:52 → 259
    CP2; CP2 transcription factor

  4. XM_063263676.1 → XP_063119746.1  alpha-globin transcription factor CP2 isoform X3

RNA

  1. XR_010052986.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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