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Tns2 tensin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315326, updated on 2-May-2024

Summary

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Official Symbol
Tns2provided by RGD
Official Full Name
tensin 2provided by RGD
Primary source
RGD:1310917
See related
Ensembl:ENSRNOG00000010588 AllianceGenome:RGD:1310917
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tenc1
Summary
Predicted to enable identical protein binding activity; kinase binding activity; and protein tyrosine phosphatase activity. Predicted to be involved in negative regulation of cell population proliferation; negative regulation of insulin receptor signaling pathway; and peptidyl-tyrosine dephosphorylation. Predicted to act upstream of or within several processes, including collagen metabolic process; multicellular organismal homeostasis; and response to muscle activity. Predicted to be located in focal adhesion. Orthologous to human TNS2 (tensin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 169.3), Heart (RPKM 103.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q36
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (135108401..135126505)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (133229746..133247889)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (143702623..143720995)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479613 Neighboring gene eukaryotic translation initiation factor 4B Neighboring gene uncharacterized LOC134479789 Neighboring gene SPRY domain containing 3 Neighboring gene insulin-like growth factor binding protein 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characteristic changes in carbohydrate profile in the kidneys of hereditary nephrotic mice (ICGN strain). Tamura K, et al. J Vet Med Sci, 2000 Apr. PMID 10823724
  2. Neuronal BC RNAs cooperate with eIF4B to mediate activity-dependent translational control. Eom T, et al. J Cell Biol, 2014 Oct 27. PMID 25332164, Free PMC Article
  3. The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2. Moon KD, et al. Biochim Biophys Acta, 2012 Feb. PMID 22019427, Free PMC Article
  4. Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression. Yam JW, et al. Cancer Res, 2006 Sep 1. PMID 16951145
  5. C1-Ten is a protein tyrosine phosphatase of insulin receptor substrate 1 (IRS-1), regulating IRS-1 stability and muscle atrophy. Koh A, et al. Mol Cell Biol, 2013 Apr. PMID 23401856, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular homeostasis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within collagen metabolic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within kidney development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism growth ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organismal-level homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of insulin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-tyrosine dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to muscle activity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tensin-2
Names
tensin like C1 domain containing phosphatase (tensin 2)
tensin-like C1 domain-containing phosphatase
NP_001101584.2
XP_008764087.1
XP_008764091.2
XP_017450825.1
XP_017450826.1
XP_017450827.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108114.2 → NP_001101584.2  tensin-2

    Status: VALIDATED

    Source sequence(s)
    BF419140, JAXUCZ010000007
    UniProtKB/TrEMBL
    M0R671
    Related
    ENSRNOP00000096207.1, ENSRNOT00000118793.1
    Conserved Domains (6) summary
    cd09927
    Location:1127 → 1240
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:779 → 1143
    PHA03247; large tegument protein UL36; Provisional
    cd00029
    Location:32 → 79
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01213
    Location:1264 → 1396
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:297 → 424
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cl28904
    Location:132 → 290
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    135108401..135126505
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017595336.3 → XP_017450825.1  tensin-2 isoform X1

    UniProtKB/TrEMBL
    F7FBH3, M0R671
    Related
    ENSRNOP00000014033.5

  2. XM_008765869.3 → XP_008764091.2  tensin-2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AEG8, M0R671
    Related
    ENSRNOP00000090796.1
    Conserved Domains (6) summary
    cd09927
    Location:1127 → 1240
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    PHA03247
    Location:779 → 1143
    PHA03247; large tegument protein UL36; Provisional
    cd01213
    Location:1264 → 1396
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:297 → 424
    PTEN_C2; C2 domain of PTEN tumor-suppressor protein
    cd20887
    Location:30 → 83
    C1_TNS2; protein kinase C conserved region 1 (C1 domain) found in tensin-2 and similar proteins
    cl28904
    Location:132 → 290
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  3. XM_008765865.3 → XP_008764087.1  tensin-2 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AKK0, M0R671
    Related
    ENSRNOP00000094945.1
    Conserved Domains (6) summary
    cd09927
    Location:1104 → 1217
    SH2_Tensin_like; Src homology 2 domain found in Tensin-like proteins
    smart00404
    Location:166 → 284
    PTPc_motif; Protein tyrosine phosphatase, catalytic domain motif
    cd00029
    Location:9 → 56
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01213
    Location:1241 → 1373
    PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain
    pfam10409
    Location:274 → 401
    PTEN_C2; C2 domain of PTEN tumour-suppressor protein
    pfam15265
    Location:918 → 1092
    FAM196; FAM196 family

  4. XM_017595338.3 → XP_017450827.1  tensin-2 isoform X4

    UniProtKB/TrEMBL
    M0R671

  5. XM_017595337.3 → XP_017450826.1  tensin-2 isoform X4

    UniProtKB/TrEMBL
    M0R671
Nucleotide Protein Strain
Heading Accession and Version

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