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Atf7 activating transcription factor 7 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315333, updated on 3-Apr-2024

Summary

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Official Symbol
Atf7provided by RGD
Official Full Name
activating transcription factor 7provided by RGD
Primary source
RGD:1304940
See related
Ensembl:ENSRNOG00000015269 AllianceGenome:RGD:1304940
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; cAMP response element binding activity; and transcription coactivator binding activity. Predicted to be involved in several processes, including animal organ development; hepatocyte apoptotic process; and regulation of transcription by RNA polymerase II. Predicted to be located in nucleoplasm. Orthologous to human ATF7 (activating transcription factor 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 47.6), Spleen (RPKM 46.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q36
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (135537351..135649188, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (133660491..133750902, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (144131382..144223463, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene Tarbp2 subunit of RISC loading complex Neighboring gene neuropeptide FF-amide peptide precursor Neighboring gene uncharacterized LOC120093744 Neighboring gene ATP synthase membrane subunit c locus 2 Neighboring gene calcium binding and coiled coil domain 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Expression of activating transcription factor 7 is correlated with prognosis of colorectal cancer. Guo HQ, et al. J Cancer Res Ther, 2015 Apr-Jun. PMID 26148593
  2. ATF-a0, a novel variant of the ATF/CREB transcription factor family, forms a dominant transcription inhibitor in ATF-a heterodimers. Pescini R, et al. J Biol Chem, 1994 Jan 14. PMID 8288576
  3. Role of the ATFa/JNK2 complex in Jun activation. De Graeve F, et al. Oncogene, 1999 Jun 10. PMID 10376527
  4. Sumoylation delays the ATF7 transcription factor subcellular localization and inhibits its transcriptional activity. Hamard PJ, et al. Nucleic Acids Res, 2007. PMID 17264123, Free PMC Article
  5. A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex. Armour SM, et al. Mol Cell Biol, 2013 Apr. PMID 23382074, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables cAMP response element binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables mitogen-activated protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in heart development ISO
Inferred from Sequence Orthology
more info
  
involved_in hematopoietic progenitor cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in hepatocyte apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in in utero embryonic development ISO
Inferred from Sequence Orthology
more info
  
involved_in liver development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cyclic AMP-dependent transcription factor ATF-7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108115.1 → NP_001101585.1  cyclic AMP-dependent transcription factor ATF-7

    See identical proteins and their annotated locations for NP_001101585.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474035
    UniProtKB/TrEMBL
    A6KCX2, G3V7X9
    Related
    ENSRNOP00000020527.5, ENSRNOT00000020527.5
    Conserved Domains (3) summary
    cd12192
    Location:47 → 84
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:336 → 396
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00017
    Location:9 → 31
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    135537351..135649188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263681.1 → XP_063119751.1  cyclic AMP-dependent transcription factor ATF-7 isoform X1

    UniProtKB/TrEMBL
    B0BMY0

  2. XM_006242396.5 → XP_006242458.1  cyclic AMP-dependent transcription factor ATF-7 isoform X1

    See identical proteins and their annotated locations for XP_006242458.1

    UniProtKB/TrEMBL
    B0BMY0, G3V7X9
    Related
    ENSRNOP00000077316.1
    Conserved Domains (3) summary
    cd12192
    Location:47 → 84
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:334 → 394
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00017
    Location:9 → 31
    ZF_C2H2; C2H2 Zn finger [structural motif]

  3. XM_008765747.4 → XP_008763969.1  cyclic AMP-dependent transcription factor ATF-7 isoform X1

    See identical proteins and their annotated locations for XP_008763969.1

    UniProtKB/TrEMBL
    B0BMY0, G3V7X9
    Related
    ENSRNOP00000085221.1
    Conserved Domains (3) summary
    cd12192
    Location:47 → 84
    GCN4_cent; GCN4 central activation domain-like acidic activation domain
    cd14687
    Location:334 → 394
    bZIP_ATF2; Basic leucine zipper (bZIP) domain of Activating Transcription Factor-2 (ATF-2) and similar proteins: a DNA-binding and dimerization domain
    sd00017
    Location:9 → 31
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. XM_063263683.1 → XP_063119753.1  cyclic AMP-dependent transcription factor ATF-7 isoform X2

Nucleotide Protein Strain
Heading Accession and Version

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