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Amotl1 angiomotin-like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315430, updated on 24-Apr-2024

Summary

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Official Symbol
Amotl1provided by RGD
Official Full Name
angiomotin-like 1provided by RGD
Primary source
RGD:1305268
See related
Ensembl:ENSRNOG00000008990 AllianceGenome:RGD:1305268
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity. Predicted to act upstream of or within establishment of cell polarity involved in ameboidal cell migration and positive regulation of blood vessel endothelial cell migration. Predicted to be located in several cellular components, including apical plasma membrane; bicellular tight junction; and lamellipodium. Predicted to be part of COP9 signalosome. Orthologous to human AMOTL1 (angiomotin like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 685.2), Lung (RPKM 153.0) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Amotl1 in Genome Data Viewer
Location:
8q12
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (19630139..19749027, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (11348651..11467564, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (13037265..13157701, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene lysine demethylase 4D Neighboring gene CWC15 spliceosome-associated protein Neighboring gene uncharacterized LOC134479993 Neighboring gene piwi-like RNA-mediated gene silencing 4 Neighboring gene sodium channel modifier 1, pseudogene 1 Neighboring gene fucosyltransferase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. JEAP, a novel component of tight junctions in exocrine cells. Nishimura M, et al. J Biol Chem, 2002 Feb 15. PMID 11733531
  2. Identification and characterization of a novel tight junction-associated family of proteins that interacts with a WW domain of MAGI-1. Patrie KM. Biochim Biophys Acta, 2005 Aug 15. PMID 16019084
  3. Molecular characterization of angiomotin/JEAP family proteins: interaction with MUPP1/Patj and their endogenous properties. Sugihara-Mizuno Y, et al. Genes Cells, 2007 Apr. PMID 17397395
  4. Angiomotin-like protein 1 controls endothelial polarity and junction stability during sprouting angiogenesis. Zheng Y, et al. Circ Res, 2009 Jul 31. PMID 19590046
  5. Characterization of the human COP9 signalosome complex using affinity purification and mass spectrometry. Fang L, et al. J Proteome Res, 2008 Nov. PMID 18850735, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within establishment of cell polarity involved in ameboidal cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within establishment of epithelial cell polarity ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of blood vessel endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of COP9 signalosome ISO
Inferred from Sequence Orthology
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
angiomotin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001429440.1 → NP_001416369.1  angiomotin-like protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  2. NM_001429441.1 → NP_001416370.1  angiomotin-like protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

  3. NM_001429442.1 → NP_001416371.1  angiomotin-like protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    19630139..19749027 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039082231.2 → XP_038938159.1  angiomotin-like protein 1 isoform X2

    UniProtKB/TrEMBL
    F1LZQ6
    Conserved Domains (2) summary
    COG1196
    Location:520 → 743
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12240
    Location:657 → 863
    Angiomotin_C; Angiomotin C terminal

  2. XM_039082232.2 → XP_038938160.1  angiomotin-like protein 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5Y7F3, F1LZQ6
    Related
    ENSRNOP00000077333.1
    Conserved Domains (2) summary
    COG1196
    Location:513 → 736
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12240
    Location:650 → 856
    Angiomotin_C; Angiomotin C terminal

  3. XM_039082230.2 → XP_038938158.1  angiomotin-like protein 1 isoform X1

    UniProtKB/TrEMBL
    F1LZQ6
    Conserved Domains (2) summary
    COG1196
    Location:521 → 744
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12240
    Location:658 → 864
    Angiomotin_C; Angiomotin C terminal

  4. XM_039082234.2 → XP_038938162.1  angiomotin-like protein 1 isoform X6

    UniProtKB/TrEMBL
    F1LZQ6
    Conserved Domains (2) summary
    COG1196
    Location:390 → 613
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12240
    Location:527 → 733
    Angiomotin_C; Angiomotin C terminal

  5. XM_039082233.2 → XP_038938161.1  angiomotin-like protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I6A227, F1LZQ6
    Related
    ENSRNOP00000084828.1
    Conserved Domains (2) summary
    COG1196
    Location:476 → 699
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam12240
    Location:613 → 819
    Angiomotin_C; Angiomotin C terminal

  6. XM_063266287.1 → XP_063122357.1  angiomotin-like protein 1 isoform X5

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108126.1: Suppressed sequence

    Description
    NM_001108126.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from mouse, laboratory: Amotl1 (GeneID:75723).
Nucleotide Protein Strain
Heading Accession and Version

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