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Tmed1 transmembrane p24 trafficking protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315461, updated on 2-May-2024

Summary

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Official Symbol
Tmed1provided by RGD
Official Full Name
transmembrane p24 trafficking protein 1provided by RGD
Primary source
RGD:1311679
See related
Ensembl:ENSRNOG00000008037 AllianceGenome:RGD:1311679
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Il1rl1l
Summary
Predicted to be involved in Golgi organization; endoplasmic reticulum to Golgi vesicle-mediated transport; and intracellular protein transport. Predicted to be located in endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; and plasma membrane. Predicted to be integral component of membrane. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi apparatus; and endoplasmic reticulum-Golgi intermediate compartment. Orthologous to human TMED1 (transmembrane p24 trafficking protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 87.5), Heart (RPKM 80.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tmed1 in Genome Data Viewer
Location:
8q13
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (28336072..28342853, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (20059937..20063567, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (22540422..22544369, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene queuine tRNA-ribosyltransferase catalytic subunit 1 Neighboring gene dynamin 2 Neighboring gene uncharacterized LOC134480146 Neighboring gene similar to human chromosome 19 open reading frame 38 Neighboring gene phosphatidylinositol glycan anchor biosynthesis, class X, pseudogene 1 Neighboring gene coactivator-associated arginine methyltransferase 1 Neighboring gene Yip1 domain family, member 2 Neighboring gene translocase of inner mitochondrial membrane 29

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Oligomeric state and stoichiometry of p24 proteins in the early secretory pathway. Jenne N, et al. J Biol Chem, 2002 Nov 29. PMID 12237308
  2. gp25L/emp24/p24 protein family members of the cis-Golgi network bind both COP I and II coatomer. Dominguez M, et al. J Cell Biol, 1998 Feb 23. PMID 9472029, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC108769

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cargo receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in COPII-coated ER to Golgi transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum-Golgi intermediate compartment membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane emp24 domain-containing protein 1
Names
interleukin-1 receptor-like 1 ligand
p24 family protein gamma-1
p24gamma1
transmembrane emp24 domain containing 1
transmembrane emp24 protein transport domain containing 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013432.1 → NP_001013450.1  transmembrane emp24 domain-containing protein 1 precursor

    See identical proteins and their annotated locations for NP_001013450.1

    Status: PROVISIONAL

    Source sequence(s)
    BC091167
    UniProtKB/Swiss-Prot
    Q5BK85
    UniProtKB/TrEMBL
    A6JNS6
    Related
    ENSRNOP00000057728.2, ENSRNOT00000061009.5
    Conserved Domains (1) summary
    pfam01105
    Location:33 → 219
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    28336072..28342853 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008765940.4 → XP_008764162.1  transmembrane emp24 domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A1Y9
    Related
    ENSRNOP00000084813.1
    Conserved Domains (1) summary
    pfam01105
    Location:33 → 233
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD

  2. XM_006242644.4 → XP_006242706.1  transmembrane emp24 domain-containing protein 1 isoform X1

    Conserved Domains (1) summary
    pfam01105
    Location:33 → 254
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5BK85.1 GenPept UniProtKB/Swiss-Prot:Q5BK85

Gene LinkOut

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