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Ubash3b ubiquitin associated and SH3 domain containing, B [ Rattus norvegicus (Norway rat) ]

Gene ID: 315579, updated on 30-Mar-2024

Summary

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Official Symbol
Ubash3bprovided by RGD
Official Full Name
ubiquitin associated and SH3 domain containing, Bprovided by RGD
Primary source
RGD:1310357
See related
Ensembl:ENSRNOG00000008187 AllianceGenome:RGD:1310357
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Sts1; Sts-1; RGD1310357
Summary
Enables ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including collagen-activated tyrosine kinase receptor signaling pathway; negative regulation of bone resorption; and platelet aggregation. Predicted to act upstream of or within several processes, including negative regulation of osteoclast differentiation; negative regulation of platelet aggregation; and platelet activation. Predicted to be active in cytoplasm. Orthologous to human UBASH3B (ubiquitin associated and SH3 domain containing B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 85.5), Brain (RPKM 68.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Ubash3b in Genome Data Viewer
Location:
8q22
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (50282510..50430034, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (41385419..41532248, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (45224053..45375450, complement)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene junctional cadherin complex regulator Neighboring gene uncharacterized LOC134480157 Neighboring gene cytotoxic and regulatory T cell molecule Neighboring gene uncharacterized LOC134480159 Neighboring gene uncharacterized LOC102555115 Neighboring gene uncharacterized LOC102555203 Neighboring gene uncharacterized LOC120094126 Neighboring gene uncharacterized LOC120094124

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. TULA-2, a novel histidine phosphatase, regulates bone remodeling by modulating osteoclast function. Back SH, et al. Cell Mol Life Sci, 2013 Apr. PMID 23149425, Free PMC Article
  2. The adaptor molecule CIN85 regulates Syk tyrosine kinase level by activating the ubiquitin-proteasome degradation pathway. Peruzzi G, et al. J Immunol, 2007 Aug 15. PMID 17675467
  3. A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in platelets. Thomas DH, et al. Blood, 2010 Oct 7. PMID 20585042, Free PMC Article
  4. TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)346, a Regulatory Site of Syk. Reppschläger K, et al. J Biol Chem, 2016 Oct 21. PMID 27609517, Free PMC Article
  5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within collagen-activated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in collagen-activated tyrosine kinase receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within collagen-activated tyrosine kinase receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of bone resorption IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of bone resorption ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of platelet aggregation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-tyrosine dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within platelet activation ISO
Inferred from Sequence Orthology
more info
  
involved_in platelet aggregation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within platelet aggregation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of osteoclast differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of osteoclast differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ubiquitin-associated and SH3 domain-containing protein B
Names
Cbl-interacting protein Sts-1
NP_001178721.1
XP_006242910.1
XP_038937342.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191792.1 → NP_001178721.1  ubiquitin-associated and SH3 domain-containing protein B

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A0A8I5YC04
    Related
    ENSRNOP00000076960.1, ENSRNOT00000102848.1
    Conserved Domains (3) summary
    cd07067
    Location:375 → 587
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    cd11936
    Location:245 → 306
    SH3_UBASH3B; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein B
    cd14301
    Location:28 → 65
    UBA_UBS3B; UBA domain found in ubiquitin-associated and SH3 domain-containing protein B (UBS3B) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    50282510..50430034 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242848.5 → XP_006242910.1  ubiquitin-associated and SH3 domain-containing protein B isoform X1

    UniProtKB/TrEMBL
    A0A8I5YC04
    Conserved Domains (3) summary
    cd07067
    Location:375 → 585
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    cd11936
    Location:245 → 306
    SH3_UBASH3B; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein B
    cd14301
    Location:28 → 65
    UBA_UBS3B; UBA domain found in ubiquitin-associated and SH3 domain-containing protein B (UBS3B) and similar proteins

  2. XM_039081414.2 → XP_038937342.1  ubiquitin-associated and SH3 domain-containing protein B isoform X2

    UniProtKB/TrEMBL
    A0A8I5YC04, F1LV21
    Related
    ENSRNOP00000010873.7
    Conserved Domains (2) summary
    cd07067
    Location:351 → 563
    HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    cd11936
    Location:221 → 282
    SH3_UBASH3B; Src homology 3 domain of Ubiquitin-associated and SH3 domain-containing protein B
Nucleotide Protein Strain
Heading Accession and Version

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