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Spx Spliceosomal protein on the X [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31558, updated on 26-Apr-2024

Summary

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Official Symbol
Spxprovided by FlyBase
Official Full Name
Spliceosomal protein on the Xprovided by FlyBase
Primary source
FLYBASE:FBgn0015818
Locus tag
Dmel_CG3780
See related
AllianceGenome:FB:FBgn0015818
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3780; Dmel\CG3780; SF3B4; spx; SPX
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Part of precatalytic spliceosome. Human ortholog(s) of this gene implicated in Nager acrofacial dysostosis. Orthologous to human SF3B4 (splicing factor 3b subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
5E3-5E3; 1-16 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6255822..6257596)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6149855..6151629)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Rabconnectin-3A Neighboring gene schlank Neighboring gene Josephin domain containing Neighboring gene Spt6 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The new gene DmX from Drosophila melanogaster encodes a novel WD-repeat protein. Kraemer C, et al. Gene, 1998 Aug 31. PMID 9729422
  2. Reagent and Data Resources for Investigation of RNA Binding Protein Functions in Drosophila melanogaster Cultured Cells. Mohr SE, et al. G3 (Bethesda), 2015 Jul 21. PMID 26199285, Free PMC Article
  3. The Spliceosomal Protein SF3B5 is a Novel Component of Drosophila SAGA that Functions in Gene Expression Independent of Splicing. Stegeman R, et al. J Mol Biol, 2016 Sep 11. PMID 27185460, Free PMC Article
  4. Drosophila PSI controls circadian period and the phase of circadian behavior under temperature cycle via tim splicing. Foley LE, et al. Elife, 2019 Nov 8. PMID 31702555, Free PMC Article
  5. The Output of Protein-Coding Genes Shifts to Circular RNAs When the Pre-mRNA Processing Machinery Is Limiting. Liang D, et al. Mol Cell, 2017 Dec 7. PMID 29174924, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in positive regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of U12-type spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2 snRNP ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of precatalytic spliceosome HDA PubMed 

General protein information

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Preferred Names
spliceosomal protein on the X
Names
CG3780-PA
Spx-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    6255822..6257596
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078503.5 → NP_511058.1  spliceosomal protein on the X [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_511058.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q24534, Q9W424
    Related
    FBpp0070859
    Conserved Domains (2) summary
    cd12334
    Location:15 → 88
    RRM1_SF3B4; RNA recognition motif 1 in splicing factor 3B subunit 4 (SF3B4) and similar proteins
    cd12335
    Location:99 → 181
    RRM2_SF3B4; RNA recognition motif 2 in splicing factor 3B subunit 4 (SF3B4) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q24534 Q24534
Q9W424 Q9W424

Gene LinkOut

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