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Mfrp membrane frizzled-related protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 315597, updated on 30-Mar-2024

Summary

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Official Symbol
Mfrpprovided by RGD
Official Full Name
membrane frizzled-related proteinprovided by RGD
Primary source
RGD:1307477
See related
Ensembl:ENSRNOG00000039107 AllianceGenome:RGD:1307477
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to act upstream of or within eye photoreceptor cell development; retina development in camera-type eye; and visual perception. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in isolated microphthalmia 5; microphthalmia; nanophthalmos; and retinitis pigmentosa. Orthologous to human MFRP (membrane frizzled-related protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 19.8), Adrenal (RPKM 5.8) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mfrp in Genome Data Viewer
Location:
8q22
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (53342483..53347696)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (44445636..44450859)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (48437720..48443421)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene Thy-1 cell surface antigen Neighboring gene ubiquitin specific peptidase 2 Neighboring gene C1q and TNF related 5 Neighboring gene ring finger protein 26

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Gene therapy for retinitis pigmentosa caused by MFRP mutations: human phenotype and preliminary proof of concept. Dinculescu A, et al. Hum Gene Ther, 2012 Apr. PMID 22142163, Free PMC Article
  2. Identification of MFRP Mutations in Chinese Families with High Hyperopia. Xu Y, et al. Optom Vis Sci, 2016 Jan. PMID 26583794
  3. Novel membrane frizzled-related protein gene mutation as cause of posterior microphthalmia resulting in high hyperopia with macular folds. Wasmann RA, et al. Acta Ophthalmol, 2014 May. PMID 23742260, Free PMC Article
  4. Compound heterozygosity for a novel and a recurrent MFRP gene mutation in a family with the nanophthalmos-retinitis pigmentosa complex. Zenteno JC, et al. Mol Vis, 2009 Sep 5. PMID 19753314, Free PMC Article
  5. Mutations in TULP1, NR2E3, and MFRP genes in Indian families with autosomal recessive retinitis pigmentosa. Kannabiran C, et al. Mol Vis, 2012. PMID 22605927, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mfrp expression increases at night in the rat pineal gland over 10-fold.
    Title: Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within eye photoreceptor cell development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within retina development in camera-type eye ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within visual perception ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
membrane frizzled-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108137.2 → NP_001101607.1  membrane frizzled-related protein

    See identical proteins and their annotated locations for NP_001101607.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    A6J3V6, D3ZU82
    Related
    ENSRNOP00000056560.2, ENSRNOT00000059813.4
    Conserved Domains (3) summary
    cd00041
    Location:307 → 419
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:266 → 300
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01392
    Location:477 → 579
    Fz; Fz domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    53342483..53347696
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006242933.5 → XP_006242995.1  membrane frizzled-related protein isoform X1

    Conserved Domains (3) summary
    cd00041
    Location:307 → 419
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:266 → 300
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01392
    Location:471 → 573
    Fz; Fz domain

  2. XM_039081419.2 → XP_038937347.1  membrane frizzled-related protein isoform X2

    Conserved Domains (3) summary
    cd00041
    Location:307 → 405
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00112
    Location:266 → 300
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam01392
    Location:453 → 555
    Fz; Fz domain
Nucleotide Protein Strain
Heading Accession and Version

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