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Dscaml1 DS cell adhesion molecule-like 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315615, updated on 11-Apr-2024

Summary

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Official Symbol
Dscaml1provided by RGD
Official Full Name
DS cell adhesion molecule-like 1provided by RGD
Primary source
RGD:1304887
See related
Ensembl:ENSRNOG00000016502 AllianceGenome:RGD:1304887
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cell-cell adhesion mediator activity and protein homodimerization activity. Predicted to be involved in several processes, including embryonic skeletal system morphogenesis; homophilic cell adhesion via plasma membrane adhesion molecules; and nervous system development. Predicted to be located in cell surface. Predicted to be active in axon and plasma membrane. Orthologous to human DSCAML1 (DS cell adhesion molecule like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 21.9) and Spleen (RPKM 1.2) See more
Orthologs
human mouse all
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Genomic context

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See Dscaml1 in Genome Data Viewer
Location:
8q22
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (54637054..54954042)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (45740298..46057322)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (49733835..50056115)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene FXYD domain-containing ion transport regulator 6 Neighboring gene FXYD domain-containing ion transport regulator 2 Neighboring gene centrosomal protein 164 Neighboring gene beta-secretase 1 Neighboring gene ring finger protein 214

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Tyrosine phosphorylation is essential for DSCAML1 to promote dendrite arborization of mouse cortical neurons. Cui S, et al. Neurosci Lett, 2013 Oct 25. PMID 24084194
  2. Down syndrome cell adhesion molecule like-1 (DSCAML1) links the GABA system and seizure susceptibility. Hayase Y, et al. Acta Neuropathol Commun, 2020 Nov 30. PMID 33256836, Free PMC Article
  3. Cloning and functional characterization of DSCAML1, a novel DSCAM-like cell adhesion molecule that mediates homophilic intercellular adhesion. Agarwala KL, et al. Biochem Biophys Res Commun, 2001 Jul 20. PMID 11453658
  4. Mammalian DSCAMs: roles in the development of the spinal cord, cortex, and cerebellum? Barlow GM, et al. Biochem Biophys Res Commun, 2002 May 10. PMID 12051741
  5. DSCAM and DSCAML1 function in self-avoidance in multiple cell types in the developing mouse retina. Fuerst PG, et al. Neuron, 2009 Nov 25. PMID 19945391, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Down syndrome cell adhesion molecule like-1 (DSCAML1) links the GABA system and seizure susceptibility.
    Title: Down syndrome cell adhesion molecule like-1 (DSCAML1) links the GABA system and seizure susceptibility.
  2. DSCAML1 promotes dendritic self-avoidance in cortical neurons, and that phosphorylation at Y1808 is essential in mediating the effects of DSCAML1.
    Title: Tyrosine phosphorylation is essential for DSCAML1 to promote dendrite arborization of mouse cortical neurons.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cell-cell adhesion mediator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in brain development ISO
Inferred from Sequence Orthology
more info
  
involved_in central nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dendrite self-avoidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dendrite self-avoidance ISO
Inferred from Sequence Orthology
more info
  
involved_in embryonic skeletal system morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cell adhesion molecule DSCAML1
Names
Down syndrome cell adhesion molecule-like 1
Down syndrome cell adhesion molecule-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108141.1 → NP_001101611.1  cell adhesion molecule DSCAML1

    See identical proteins and their annotated locations for NP_001101611.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473975
    UniProtKB/TrEMBL
    A6J449, D3ZPL7
    Related
    ENSRNOP00000022476.4, ENSRNOT00000022476.5
    Conserved Domains (9) summary
    cd00096
    Location:673 → 739
    Ig; Immunoglobulin domain
    cd05734
    Location:765 → 843
    Ig7_DSCAM; Seventh immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)
    smart00408
    Location:298 → 359
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:101 → 173
    IG; Immunoglobulin
    smart00410
    Location:665 → 744
    IG_like; Immunoglobulin like
    cd00063
    Location:1442 → 1532
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam07679
    Location:291 → 369
    I-set; Immunoglobulin I-set domain
    pfam00041
    Location:1151 → 1237
    fn3; Fibronectin type III domain
    cl11960
    Location:861 → 949
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    54637054..54954042
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039081433.2 → XP_038937361.2  cell adhesion molecule DSCAML1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A722

  2. XM_039081435.2 → XP_038937363.1  cell adhesion molecule DSCAML1 isoform X2

    Conserved Domains (7) summary
    cd00063
    Location:874 → 964
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam00041
    Location:583 → 669
    fn3; Fibronectin type III domain
    pfam13927
    Location:795 → 857
    Ig_3; Immunoglobulin domain
    cd00096
    Location:3 → 7
    Ig; Ig strand A' [structural motif]
    cd05734
    Location:179 → 275
    Ig_DSCAM; Immunoglobulin (Ig)-like domain of Down Syndrome Cell Adhesion molecule (DSCAM)
    cd05735
    Location:276 → 376
    Ig_DSCAM; Immunoglobulin (Ig) domain of Down Syndrome Cell Adhesion molecule (DSCAM)
    cl11960
    Location:1 → 83
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version

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