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Poglut3 protein O-glucosyltransferase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 315664, updated on 27-Mar-2024

Summary

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Official Symbol
Poglut3provided by RGD
Official Full Name
protein O-glucosyltransferase 3provided by RGD
Primary source
RGD:1562027
See related
Ensembl:ENSRNOG00000007177 AllianceGenome:RGD:1562027
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kdelc2
Summary
Predicted to enable UDP-glucosyltransferase activity and UDP-xylosyltransferase activity. Predicted to be involved in protein O-linked glycosylation via serine. Predicted to be located in endoplasmic reticulum lumen. Predicted to be active in endomembrane system. Orthologous to human POGLUT3 (protein O-glucosyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 177.7), Lung (RPKM 141.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Poglut3 in Genome Data Viewer
Location:
8q24
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (62673811..62691606)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (53777614..53795404)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (57964988..57982605)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene DEAD-box helicase 10 Neighboring gene anaphase promoting complex subunit 15, pseudogene 1 Neighboring gene exophilin 5 Neighboring gene uncharacterized LOC120094158 Neighboring gene similar to human chromosome 11 open reading frame 65 Neighboring gene ATM serine/threonine kinase Neighboring gene uncharacterized LOC120094159

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Two novel protein O-glucosyltransferases that modify sites distinct from POGLUT1 and affect Notch trafficking and signaling. Takeuchi H, et al. Proc Natl Acad Sci U S A, 2018 Sep 4. PMID 30127001, Free PMC Article
  2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables EGF-domain serine glucosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables EGF-domain serine xylosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables UDP-glucosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables UDP-glucosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables UDP-xylosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables UDP-xylosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables glucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in protein O-linked glycosylation via serine ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation via serine ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum lumen IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein O-glucosyltransferase 3
Names
KDEL (Lys-Asp-Glu-Leu) containing 2
KDEL motif containing 2
KDEL motif-containing protein 2
protein O-xylosyltransferase POGLUT3
NP_001020294.3
XP_063121533.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025123.3 → NP_001020294.3  protein O-glucosyltransferase 3 precursor

    See identical proteins and their annotated locations for NP_001020294.3

    Status: VALIDATED

    Source sequence(s)
    BC093594, BC100617, BU759576, JAXUCZ010000008
    UniProtKB/Swiss-Prot
    Q497C8, Q566E5
    UniProtKB/TrEMBL
    A6J4J1
    Related
    ENSRNOP00000009497.5, ENSRNOT00000009497.6
    Conserved Domains (2) summary
    cl23835
    Location:152 → 486
    Glyco_transf_90; Glycosyl transferase family 90
    pfam00630
    Location:27 → 131
    Filamin; Filamin/ABP280 repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    62673811..62691606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265463.1 → XP_063121533.1  protein O-glucosyltransferase 3 isoform X1

RNA

  1. XR_010053963.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q566E5.1 GenPept UniProtKB/Swiss-Prot:Q566E5

Gene LinkOut

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