Gldn gliomedin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Gldnprovided by RGD
Official Full Name: gliomedinprovided by RGD
Primary source: RGD:727879
See related: Ensembl:ENSRNOG00000024082 AllianceGenome:RGD:727879
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Colm; Crgl2
Summary: Predicted to enable protein binding activity involved in heterotypic cell-cell adhesion. Predicted to act upstream of or within clustering of voltage-gated sodium channels; heterotypic cell-cell adhesion; and microvillus organization. Predicted to be located in cell surface; extracellular space; and plasma membrane. Predicted to be part of collagen trimer. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome. Orthologous to human GLDN (gliomedin). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 18.2), Muscle (RPKM 13.0) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (63575270..63619346)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (54679015..54723198)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (58870516..58914605)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The crystallization of the rat GLDN olfactomedin domain was expressed in an insect-cell system.
Title: Expression, purification, crystallization and preliminary X-ray crystallographic analysis of the extracellular olfactomedin domain of gliomedin.
Primary immune reaction against gliomedin, a peripheral nervous system adhesion molecule, can be responsible for the initiation or progression of the demyelinating form of Guillain-Barre syndrome.
Title: Antibodies to gliomedin cause peripheral demyelinating neuropathy and the dismantling of the nodes of Ranvier.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Clom (e-PCR), detects polymorphism
- UniSTS:265063

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein binding involved in heterotypic cell-cell adhesion	IEA Inferred from Electronic Annotation more info
enables protein binding involved in heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in clustering of voltage-gated sodium channels	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within clustering of voltage-gated sodium channels	ISO Inferred from Sequence Orthology more info
involved_in heterotypic cell-cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in microvillus organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within microvillus organization	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
part_of collagen trimer	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: gliomedin

Names: collomin; olfactomedin-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181382.3 → NP_852047.2 gliomedin

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

Q80WL1

UniProtKB/TrEMBL

A6J4L1, G3V8X4

Related

ENSRNOP00000029833.2, ENSRNOT00000033900.3

Conserved Domains (2) summary

pfam01391
Location:157 → 220

Collagen; Collagen triple helix repeat (20 copies)

pfam02191
Location:301 → 539

OLF; Olfactomedin-like domain