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Daam2 dishevelled associated activator of morphogenesis 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316201, updated on 13-Apr-2024

Summary

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Symbol
Daam2provided by RGD
Full Name
dishevelled associated activator of morphogenesis 2provided by RGD
Primary source
RGD:1306128
See related
Ensembl:ENSRNOG00000053945 AllianceGenome:RGD:1306128
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable actin binding activity and small GTPase binding activity. Predicted to be involved in nervous system development and regulation of Wnt signaling pathway. Predicted to act upstream of or within determination of left/right symmetry. Orthologous to human DAAM2 (dishevelled associated activator of morphogenesis 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 91.3), Testes (RPKM 73.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Daam2 in Genome Data Viewer
Location:
9q12
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (18926620..19044672)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (11428913..11546982)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (13444883..13493154)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene potassium two pore domain channel subfamily K member 16, pseudogene 1 Neighboring gene kinesin family member 6 Neighboring gene uncharacterized LOC134480334 Neighboring gene uncharacterized LOC134480336 Neighboring gene uncharacterized LOC120094630 Neighboring gene molybdenum cofactor synthesis 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Knockdown of disheveled-associated activator of morphogenesis 2 disrupts cytoskeletal organization and phagocytosis in rat Sertoli cells. Xu J, et al. Mol Cell Endocrinol, 2023 Mar 1. PMID 36681175
  2. Daam2 is required for dorsal patterning via modulation of canonical Wnt signaling in the developing spinal cord. Lee HK, et al. Dev Cell, 2012 Jan 17. PMID 22227309, Free PMC Article
  3. Integration of left-right Pitx2 transcription and Wnt signaling drives asymmetric gut morphogenesis via Daam2. Welsh IC, et al. Dev Cell, 2013 Sep 30. PMID 24091014, Free PMC Article
  4. Daam2-PIP5K is a regulatory pathway for Wnt signaling and therapeutic target for remyelination in the CNS. Lee HK, et al. Neuron, 2015 Mar 18. PMID 25754822, Free PMC Article
  5. Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. Kang D, et al. J Proteome Res, 2008 Aug. PMID 18570454

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockdown of disheveled-associated activator of morphogenesis 2 disrupts cytoskeletal organization and phagocytosis in rat Sertoli cells.
    Title: Knockdown of disheveled-associated activator of morphogenesis 2 disrupts cytoskeletal organization and phagocytosis in rat Sertoli cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within determination of left/right symmetry ISO
Inferred from Sequence Orthology
more info
  
involved_in dorsal spinal cord development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in podocyte cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin cytoskeleton organization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of actin filament polymerization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of filopodium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of non-canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
disheveled-associated activator of morphogenesis 2
Names
disheveled-associated activator of morphogenesis 2-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427649.1 → NP_001414578.1  disheveled-associated activator of morphogenesis 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A8I6B158

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    18926620..19044672
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039084447.2 → XP_038940375.1  disheveled-associated activator of morphogenesis 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K988
    Related
    ENSRNOP00000074902.2
    Conserved Domains (3) summary
    pfam06367
    Location:231 → 435
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:587 → 1008
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:43 → 228
    Drf_GBD; Diaphanous GTPase-binding Domain

  2. XM_063267081.1 → XP_063123151.1  disheveled-associated activator of morphogenesis 2 isoform X3

  3. XM_039084452.2 → XP_038940380.1  disheveled-associated activator of morphogenesis 2 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K988
    Conserved Domains (3) summary
    pfam06367
    Location:231 → 435
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:587 → 1001
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:43 → 228
    Drf_GBD; Diaphanous GTPase-binding Domain

  4. XM_039084455.2 → XP_038940383.1  disheveled-associated activator of morphogenesis 2 isoform X5

    Conserved Domains (3) summary
    pfam06367
    Location:231 → 435
    Drf_FH3; Diaphanous FH3 Domain
    pfam06371
    Location:43 → 228
    Drf_GBD; Diaphanous GTPase-binding Domain
    cl19758
    Location:587 → 643
    FH2; Formin Homology 2 Domain

  5. XM_039084450.2 → XP_038940378.1  disheveled-associated activator of morphogenesis 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K988
    Conserved Domains (3) summary
    pfam06367
    Location:231 → 435
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:587 → 1008
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:43 → 228
    Drf_GBD; Diaphanous GTPase-binding Domain

  6. XM_039084449.2 → XP_038940377.1  disheveled-associated activator of morphogenesis 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K988
    Conserved Domains (3) summary
    pfam06367
    Location:231 → 435
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:587 → 1008
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:43 → 228
    Drf_GBD; Diaphanous GTPase-binding Domain

  7. XM_039084451.2 → XP_038940379.1  disheveled-associated activator of morphogenesis 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K988
    Conserved Domains (3) summary
    pfam06367
    Location:231 → 435
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:587 → 1008
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:43 → 228
    Drf_GBD; Diaphanous GTPase-binding Domain

  8. XM_039084448.2 → XP_038940376.1  disheveled-associated activator of morphogenesis 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K988
    Conserved Domains (3) summary
    pfam06367
    Location:231 → 435
    Drf_FH3; Diaphanous FH3 Domain
    pfam02181
    Location:587 → 1008
    FH2; Formin Homology 2 Domain
    pfam06371
    Location:43 → 228
    Drf_GBD; Diaphanous GTPase-binding Domain

  9. XM_063267082.1 → XP_063123152.1  disheveled-associated activator of morphogenesis 2 isoform X4

    UniProtKB/TrEMBL
    A0A8I6B158

RNA

  1. XR_010054590.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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