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Taf8 TATA-box binding protein associated factor 8 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316216, updated on 5-Mar-2024

Summary

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Official Symbol
Taf8provided by RGD
Official Full Name
TATA-box binding protein associated factor 8provided by RGD
Primary source
RGD:1308423
See related
Ensembl:ENSRNOG00000015249 AllianceGenome:RGD:1308423
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tbn
Summary
Predicted to enable protein heterodimerization activity. Predicted to be involved in maintenance of protein location in nucleus and transcription initiation from RNA polymerase II promoter. Predicted to act upstream of or within DNA-templated transcription open complex formation; inner cell mass cell proliferation; and regulation of fat cell differentiation. Predicted to be located in nucleoplasm and perinuclear region of cytoplasm. Predicted to be part of transcription factor TFIID complex. Orthologous to human TAF8 (TATA-box binding protein associated factor 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 84.7), Spleen (RPKM 66.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
9q12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (20989554..21009541)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (13491892..13511713)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (15513048..15532992)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene cyclin D3 Neighboring gene uncharacterized LOC134480552 Neighboring gene uncharacterized LOC134480554 Neighboring gene similar to human chromosome 6 open reading frame 132 Neighboring gene uncharacterized LOC134480553 Neighboring gene ciliary microtubule inner protein 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Taube nuss is a novel gene essential for the survival of pluripotent cells of early mouse embryos. Voss AK, et al. Development, 2000 Dec. PMID 11076765
  2. The nuclear import of TAF10 is regulated by one of its three histone fold domain-containing interaction partners. Soutoglou E, et al. Mol Cell Biol, 2005 May. PMID 15870280, Free PMC Article
  3. Structural bioinformatics of the general transcription factor TFIID. Malkowska M, et al. Biochimie, 2013 Apr. PMID 23146842
  4. Structure of promoter-bound TFIID and model of human pre-initiation complex assembly. Louder RK, et al. Nature, 2016 Mar 31. PMID 27007846, Free PMC Article
  5. The TBN protein, which is essential for early embryonic mouse development, is an inducible TAFII implicated in adipogenesis. Guermah M, et al. Mol Cell, 2003 Oct. PMID 14580349

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein heterodimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription open complex formation ISO
Inferred from Sequence Orthology
more info
  
involved_in RNA polymerase II preinitiation complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within inner cell mass cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in maintenance of protein location in nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription initiation by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in transcription initiation at RNA polymerase II promoter IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
part_of transcription factor TFIID complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of transcription factor TFIID complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
transcription initiation factor TFIID subunit 8
Names
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor
TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factorq
taube nuss homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108197.1 → NP_001101667.1  transcription initiation factor TFIID subunit 8

    See identical proteins and their annotated locations for NP_001101667.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473987
    UniProtKB/TrEMBL
    A0A8I6AWS9, A6JIJ8, D3ZY89
    Related
    ENSRNOP00000097776.1, ENSRNOT00000094728.1
    Conserved Domains (2) summary
    cd08049
    Location:142 → 195
    TAF8; TATA Binding Protein (TBP) Associated Factor 8
    pfam07524
    Location:27 → 104
    Bromo_TP; Bromodomain associated

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    20989554..21009541
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008766860.3 → XP_008765082.1  transcription initiation factor TFIID subunit 8 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZZ64
    Related
    ENSRNOP00000083321.1, ENSRNOT00000101782.1
    Conserved Domains (2) summary
    cd08049
    Location:142 → 195
    TAF8; TATA Binding Protein (TBP) Associated Factor 8
    pfam07524
    Location:27 → 104
    Bromo_TP; Bromodomain associated

  2. XM_039083489.2 → XP_038939417.1  transcription initiation factor TFIID subunit 8 isoform X3

    UniProtKB/TrEMBL
    A6JIJ7
    Conserved Domains (2) summary
    cd08049
    Location:142 → 195
    TAF8; TATA Binding Protein (TBP) Associated Factor 8
    pfam07524
    Location:27 → 104
    Bromo_TP; Bromodomain associated

  3. XM_039083490.2 → XP_038939418.1  transcription initiation factor TFIID subunit 8 isoform X3

    UniProtKB/TrEMBL
    A6JIJ7
    Conserved Domains (2) summary
    cd08049
    Location:142 → 195
    TAF8; TATA Binding Protein (TBP) Associated Factor 8
    pfam07524
    Location:27 → 104
    Bromo_TP; Bromodomain associated

  4. XM_008766862.4 → XP_008765084.1  transcription initiation factor TFIID subunit 8 isoform X2

    UniProtKB/TrEMBL
    A0A8I6B3B9, A6JIJ6
    Related
    ENSRNOP00000095795.1
    Conserved Domains (2) summary
    cd08049
    Location:142 → 195
    TAF8; TATA Binding Protein (TBP) Associated Factor 8
    pfam07524
    Location:27 → 104
    Bromo_TP; Bromodomain associated
Nucleotide Protein Strain
Heading Accession and Version

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