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Tjap1 tight junction associated protein 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316233, updated on 13-Apr-2024

Summary

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Official Symbol
Tjap1provided by RGD
Official Full Name
tight junction associated protein 1provided by RGD
Primary source
RGD:1308708
See related
Ensembl:ENSRNOG00000018980 AllianceGenome:RGD:1308708
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Tjp4
Summary
Predicted to be involved in Golgi organization. Predicted to be located in Golgi apparatus; endosome; and plasma membrane. Predicted to be active in trans-Golgi network. Orthologous to human TJAP1 (tight junction associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 88.3), Adrenal (RPKM 52.9) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Tjap1 in Genome Data Viewer
Location:
9q12
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (22198984..22223201)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (14701418..14725623)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (17086452..17110770)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily C member 10 Neighboring gene delta like non-canonical Notch ligand 2 Neighboring gene U6 spliceosomal RNA Neighboring gene leucine rich repeat containing 73 Neighboring gene Yip1 domain family, member 3 Neighboring gene RNA polymerase I and III subunit C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Pilt is a coiled-coil domain-containing protein that localizes at the trans-Golgi complex and regulates its structure. Tamaki H, et al. FEBS Lett, 2012 Sep 21. PMID 22841714
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within Golgi organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in trans-Golgi network ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
tight junction-associated protein 1
Names
tight junction protein 4 (peripheral)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108203.2 → NP_001101673.1  tight junction-associated protein 1

    See identical proteins and their annotated locations for NP_001101673.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A0G2K0W5, A6JIR8, D3ZU31
    Conserved Domains (2) summary
    COG1196
    Location:17 → 161
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:275 → 542
    Pilt; Protein incorporated later into Tight Junctions

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    22198984..22223201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006244529.5 → XP_006244591.1  tight junction-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006244591.1

    UniProtKB/TrEMBL
    A0A0G2K0W5, A0A8I6GDP5
    Conserved Domains (2) summary
    COG1196
    Location:17 → 171
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:285 → 552
    Pilt; Protein incorporated later into Tight Junctions

  2. XM_063267096.1 → XP_063123166.1  tight junction-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GDP5

  3. XM_063267110.1 → XP_063123180.1  tight junction-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    A6JIR8, D3ZU31

  4. XM_063267097.1 → XP_063123167.1  tight junction-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GDP5

  5. XM_017596429.3 → XP_017451918.1  tight junction-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    A0A0G2K0W5, A6JIR8, D3ZU31
    Related
    ENSRNOP00000025660.3
    Conserved Domains (2) summary
    COG1196
    Location:17 → 161
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:275 → 542
    Pilt; Protein incorporated later into Tight Junctions

  6. XM_063267102.1 → XP_063123172.1  tight junction-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    A6JIR8, D3ZU31

  7. XM_063267103.1 → XP_063123173.1  tight junction-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    A6JIR8, D3ZU31

  8. XM_063267104.1 → XP_063123174.1  tight junction-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    A6JIR8, D3ZU31

  9. XM_039083524.2 → XP_038939452.1  tight junction-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K0W5, A0A8I6GDP5
    Conserved Domains (2) summary
    COG1196
    Location:17 → 171
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:285 → 552
    Pilt; Protein incorporated later into Tight Junctions

  10. XM_063267100.1 → XP_063123170.1  tight junction-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GDP5

  11. XM_039083522.2 → XP_038939450.1  tight junction-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K0W5, A0A8I6GDP5
    Conserved Domains (2) summary
    COG1196
    Location:17 → 171
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:285 → 552
    Pilt; Protein incorporated later into Tight Junctions

  12. XM_063267099.1 → XP_063123169.1  tight junction-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GDP5

  13. XM_063267107.1 → XP_063123177.1  tight junction-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    A6JIR8, D3ZU31

  14. XM_063267108.1 → XP_063123178.1  tight junction-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    A6JIR8, D3ZU31

  15. XM_017596425.3 → XP_017451914.1  tight junction-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K0W5, A0A8I6GDP5
    Conserved Domains (2) summary
    COG1196
    Location:17 → 171
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:285 → 552
    Pilt; Protein incorporated later into Tight Junctions

  16. XM_063267106.1 → XP_063123176.1  tight junction-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    A6JIR8, D3ZU31

  17. XM_063267105.1 → XP_063123175.1  tight junction-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    A6JIR8, D3ZU31

  18. XM_063267109.1 → XP_063123179.1  tight junction-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    A6JIR8, D3ZU31

  19. XM_063267112.1 → XP_063123182.1  tight junction-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    A6JIR8, D3ZU31

  20. XM_039083529.2 → XP_038939457.1  tight junction-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K0W5, A0A8I6GDP5
    Conserved Domains (2) summary
    COG1196
    Location:17 → 171
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:285 → 552
    Pilt; Protein incorporated later into Tight Junctions

  21. XM_063267111.1 → XP_063123181.1  tight junction-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    A6JIR8, D3ZU31

  22. XM_063267098.1 → XP_063123168.1  tight junction-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GDP5

  23. XM_039083523.2 → XP_038939451.1  tight junction-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K0W5, A0A8I6GDP5
    Conserved Domains (2) summary
    COG1196
    Location:17 → 171
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:285 → 552
    Pilt; Protein incorporated later into Tight Junctions

  24. XM_017596424.3 → XP_017451913.1  tight junction-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K0W5, A0A8I6GDP5
    Related
    ENSRNOP00000086121.1
    Conserved Domains (2) summary
    COG1196
    Location:17 → 171
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:285 → 552
    Pilt; Protein incorporated later into Tight Junctions

  25. XM_039083525.2 → XP_038939453.1  tight junction-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K0W5, A0A8I6GDP5
    Conserved Domains (2) summary
    COG1196
    Location:17 → 171
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam15453
    Location:285 → 552
    Pilt; Protein incorporated later into Tight Junctions

  26. XM_039083530.2 → XP_038939458.1  tight junction-associated protein 1 isoform X3

    Conserved Domains (1) summary
    pfam15453
    Location:151 → 418
    Pilt; Protein incorporated later into Tight Junctions
Nucleotide Protein Strain
Heading Accession and Version

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