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Aox2 aldehyde oxidase 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316421, updated on 6-Jun-2024

Summary

Official Symbol
Aox2provided by RGD
Official Full Name
aldehyde oxidase 2provided by RGD
Primary source
RGD:1359668
See related
Ensembl:ENSRNOG00000033923 AllianceGenome:RGD:1359668
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Aox2p; Aox3l1
Summary
Predicted to enable several functions, including 2 iron, 2 sulfur cluster binding activity; molybdopterin cofactor binding activity; and oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor. Predicted to be involved in xenobiotic metabolic process. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 42.4), Kidney (RPKM 34.3) and 3 other tissues See more
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Genomic context

See Aox2 in Genome Data Viewer
Location:
9q31
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (67322291..67411694)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (59828403..59916175)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (65175455..65265149)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene aldehyde oxidase 4 Neighboring gene uncharacterized LOC103690538 Neighboring gene ribosomal protein L21 like 4 Neighboring gene basic leucine zipper and W2 domains 1 Neighboring gene CDC-like kinase 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

General gene information

Markers

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables 2 iron, 2 sulfur cluster binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables FAD binding IEA
Inferred from Electronic Annotation
more info
 
enables NAD binding IEA
Inferred from Electronic Annotation
more info
 
enables aldehyde oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables aldehyde oxidase activity IEA
Inferred from Electronic Annotation
more info
 
enables aldehyde oxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables flavin adenine dinucleotide binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
 
enables iron ion binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables molybdopterin cofactor binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in xenobiotic metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
aldehyde oxidase 2
Names
aldehyde oxidase 2 pseudogene
aldehyde oxidase 3-like 1
aldehyde oxidase homolog 3
azaheterocycle hydroxylase 2
NP_001008522.2
XP_063123258.1
XP_063123259.1
XP_063123260.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001008522.2NP_001008522.2  aldehyde oxidase 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    D4A6S5, Q5QE78
    UniProtKB/TrEMBL
    A0A096P6M6
    Related
    ENSRNOP00000047535.4, ENSRNOT00000048027.5
    Conserved Domains (1) summary
    TIGR02969
    Location:101344
    mam_aldehyde_ox; aldehyde oxidase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    67322291..67411694
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063267188.1XP_063123258.1  aldehyde oxidase 2 isoform X1

    UniProtKB/Swiss-Prot
    D4A6S5, Q5QE78
  2. XM_063267189.1XP_063123259.1  aldehyde oxidase 2 isoform X2

  3. XM_063267190.1XP_063123260.1  aldehyde oxidase 2 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZNK8