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Slc19a3 solute carrier family 19 member 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316559, updated on 5-Mar-2024

Summary

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Official Symbol
Slc19a3provided by RGD
Official Full Name
solute carrier family 19 member 3provided by RGD
Primary source
RGD:1311413
See related
Ensembl:ENSRNOG00000057256 AllianceGenome:RGD:1311413
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable thiamine transmembrane transporter activity. Predicted to be involved in thiamine transmembrane transport. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Biomarker of chronic kidney disease. Human ortholog(s) of this gene implicated in biotin-responsive basal ganglia disease. Orthologous to human SLC19A3 (solute carrier family 19 member 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 91.1) See more
Orthologs
human mouse all
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Genomic context

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See Slc19a3 in Genome Data Viewer
Location:
9q35
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (91723799..91747499, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (84275722..84299368, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (88762775..88828553, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L30-like Neighboring gene keratin-associated protein 5-2-like Neighboring gene small cysteine and glycine repeat-containing protein 6-like Neighboring gene C-C motif chemokine ligand 20

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Effect of chronic kidney disease on the expression of thiamin and folic acid transporters. Bukhari FJ, et al. Nephrol Dial Transplant, 2011 Jul. PMID 21149507, Free PMC Article
  2. Impaired intestinal vitamin B1 (thiamin) uptake in thiamin transporter-2-deficient mice. Reidling JC, et al. Gastroenterology, 2010 May. PMID 19879271, Free PMC Article
  3. Animal species differences in the pyridoxine transport function of SLC19A3: Absence of Slc19a3-mediated pyridoxine uptake in the rat small intestine. Yamashiro T, et al. Drug Metab Pharmacokinet, 2022 Jun. PMID 35512554
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Animal species differences in the pyridoxine transport function of SLC19A3: Absence of Slc19a3-mediated pyridoxine uptake in the rat small intestine.
    Title: Animal species differences in the pyridoxine transport function of SLC19A3: Absence of Slc19a3-mediated pyridoxine uptake in the rat small intestine.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables thiamine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables thiamine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in pyridoxine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in thiamine diphosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in thiamine transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in thiamine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
thiamine transporter 2
Names
solute carrier family 19 (sodium/hydrogen exchanger), member 3
solute carrier family 19 (thiamine transporter), member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108228.1 → NP_001101698.1  thiamine transporter 2

    See identical proteins and their annotated locations for NP_001101698.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474004
    UniProtKB/TrEMBL
    A6JWB5
    Conserved Domains (1) summary
    pfam01770
    Location:11 → 428
    Folate_carrier; Reduced folate carrier

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    91723799..91747499 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083688.2 → XP_038939616.1  thiamine transporter 2 isoform X2

    Conserved Domains (1) summary
    pfam01770
    Location:11 → 429
    Folate_carrier; Reduced folate carrier

  2. XM_039083686.2 → XP_038939614.1  thiamine transporter 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K171
    Related
    ENSRNOP00000071722.2
    Conserved Domains (1) summary
    pfam01770
    Location:14 → 432
    Folate_carrier; Reduced folate carrier

  3. XM_039083687.2 → XP_038939615.1  thiamine transporter 2 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K171
    Conserved Domains (1) summary
    pfam01770
    Location:14 → 432
    Folate_carrier; Reduced folate carrier
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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