U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hjurp Holliday junction recognition protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 316602, updated on 13-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Hjurpprovided by RGD
Official Full Name
Holliday junction recognition proteinprovided by RGD
Primary source
RGD:1305846
See related
Ensembl:ENSRNOG00000022911 AllianceGenome:RGD:1305846
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1305846
Summary
Predicted to enable histone binding activity and identical protein binding activity. Predicted to be involved in several processes, including CENP-A containing chromatin assembly; regulation of DNA binding activity; and regulation of protein-containing complex assembly. Predicted to be located in kinetochore; mitochondrion; and nuclear lumen. Predicted to be active in chromosome, centromeric region. Orthologous to human HJURP (Holliday junction recognition protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 79.0), Spleen (RPKM 61.1) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Hjurp in Genome Data Viewer
Location:
9q35
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (96301183..96315587, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (88853379..88867730, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (95347739..95362228, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene UDP glucuronosyltransferase family 1 member A9 Neighboring gene UDP glucuronosyltransferase family 1 member A8 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A7C Neighboring gene UDP glucuronosyltransferase family 1 member A6 Neighboring gene UDP glucuronosyltransferase family 1 member A5 Neighboring gene UDP glycosyltransferase 1 family, polypeptide A3 Neighboring gene UDP glucuronosyltransferase 1 family, polypeptide A2 Neighboring gene DnaJ heat shock protein family (Hsp40) member B3 Neighboring gene UDP glucuronosyltransferase family 1 member A1 Neighboring gene maestro heat-like repeat family member 2A Neighboring gene transient receptor potential cation channel, subfamily M, member 8 Neighboring gene peptidylprolyl isomerase D, pseudogene 21 Neighboring gene uncharacterized LOC108351971

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Dimerization of the CENP-A assembly factor HJURP is required for centromeric nucleosome deposition. Zasadzińska E, et al. EMBO J, 2013 Jul 31. PMID 23771058, Free PMC Article
  2. HJURP is a cell-cycle-dependent maintenance and deposition factor of CENP-A at centromeres. Dunleavy EM, et al. Cell, 2009 May 1. PMID 19410545
  3. Roles of Mis18α in epigenetic regulation of centromeric chromatin and CENP-A loading. Kim IS, et al. Mol Cell, 2012 May 11. PMID 22516971
  4. Histone chaperones in nucleosome assembly and human disease. Burgess RJ, et al. Nat Struct Mol Biol, 2013 Jan. PMID 23288364, Free PMC Article
  5. Structure of a CENP-A-histone H4 heterodimer in complex with chaperone HJURP. Hu H, et al. Genes Dev, 2011 May 1. PMID 21478274, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in CENP-A containing chromatin assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in CENP-A containing chromatin assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in chromosome segregation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in chromosome, centromeric region IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in chromosome, centromeric region ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in kinetochore ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Holliday junction recognition protein

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191813.1 → NP_001178742.1  Holliday junction recognition protein

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    D4A1W1
    Conserved Domains (3) summary
    pfam10384
    Location:11 → 68
    Scm3; Centromere protein Scm3
    pfam12346
    Location:254 → 373
    HJURP_mid; Holliday junction recognition protein-associated repeat
    pfam12347
    Location:393 → 451
    HJURP_C; Holliday junction regulator protein family C-terminal repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    96301183..96315587 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006245393.5 → XP_006245455.1  Holliday junction recognition protein isoform X1

    UniProtKB/TrEMBL
    D4A1W1
    Related
    ENSRNOP00000040906.5
    Conserved Domains (3) summary
    pfam10384
    Location:11 → 68
    Scm3; Centromere protein Scm3
    pfam12346
    Location:259 → 378
    HJURP_mid; Holliday junction recognition protein-associated repeat
    pfam12347
    Location:398 → 456
    HJURP_C; Holliday junction regulator protein family C-terminal repeat
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous