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Asb1 ankyrin repeat and SOCS box-containing 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316628, updated on 3-Apr-2024

Summary

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Official Symbol
Asb1provided by RGD
Official Full Name
ankyrin repeat and SOCS box-containing 1provided by RGD
Primary source
RGD:1310760
See related
Ensembl:ENSRNOG00000020322 AllianceGenome:RGD:1310760
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to contribute to ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination. Predicted to act upstream of or within male genitalia development. Predicted to be part of ubiquitin ligase complex. Orthologous to human ASB1 (ankyrin repeat and SOCS box containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 105.8), Spleen (RPKM 91.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Asb1 in Genome Data Viewer
Location:
9q36
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (99566852..99588321)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (92120332..92140790)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (98668231..98689471)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134480413 Neighboring gene TRAF3 interacting protein 1 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134480414 Neighboring gene uncharacterized LOC102548291

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Functional analysis of Asb-1 using genetic modification in mice. Kile BT, et al. Mol Cell Biol, 2001 Sep. PMID 11509662, Free PMC Article
  2. ASB proteins interact with Cullin5 and Rbx2 to form E3 ubiquitin ligase complexes. Kohroki J, et al. FEBS Lett, 2005 Dec 19. PMID 16325183
  3. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
  4. A germline-specific class of small RNAs binds mammalian Piwi proteins. Girard A, et al. Nature, 2006 Jul 13. PMID 16751776
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
contributes_to ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within male genitalia development ISO
Inferred from Sequence Orthology
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ubiquitin ligase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ankyrin repeat and SOCS box protein 1
Names
ankyrin repeat and SOCS box-containing protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108232.2 → NP_001101702.1  ankyrin repeat and SOCS box protein 1

    See identical proteins and their annotated locations for NP_001101702.1

    Status: PROVISIONAL

    Source sequence(s)
    BC168978
    UniProtKB/TrEMBL
    B5DF97, F7F1S8
    Related
    ENSRNOP00000027528.6, ENSRNOT00000027528.6
    Conserved Domains (4) summary
    PHA02875
    Location:80 → 266
    PHA02875; ankyrin repeat protein; Provisional
    cd03720
    Location:294 → 335
    SOCS_ASB1; SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
    sd00045
    Location:79 → 108
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:82 → 173
    Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    99566852..99588321
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039083762.2 → XP_038939690.1  ankyrin repeat and SOCS box protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZYZ6, F7F1S8
    Related
    ENSRNOP00000084202.1
    Conserved Domains (5) summary
    PHA02875
    Location:84 → 270
    PHA02875; ankyrin repeat protein; Provisional
    cd03720
    Location:298 → 339
    SOCS_ASB1; SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
    sd00045
    Location:83 → 112
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:86 → 177
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:26 → 112
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_039083763.2 → XP_038939691.1  ankyrin repeat and SOCS box protein 1 isoform X3

    UniProtKB/TrEMBL
    F7F1S8
    Conserved Domains (5) summary
    PHA02875
    Location:76 → 262
    PHA02875; ankyrin repeat protein; Provisional
    cd03720
    Location:290 → 331
    SOCS_ASB1; SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
    sd00045
    Location:75 → 104
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:78 → 169
    Ank_2; Ankyrin repeats (3 copies)
    cl39094
    Location:18 → 104
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_063267322.1 → XP_063123392.1  ankyrin repeat and SOCS box protein 1 isoform X6

    UniProtKB/TrEMBL
    A6JQT1

  4. XM_006245410.5 → XP_006245472.1  ankyrin repeat and SOCS box protein 1 isoform X4

    UniProtKB/TrEMBL
    F7F1S8
    Conserved Domains (5) summary
    cd00204
    Location:72 → 205
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03720
    Location:287 → 328
    SOCS_ASB1; SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
    pfam12796
    Location:75 → 166
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:30 → 91
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:72 → 101
    ANK; ANK repeat [structural motif]

  5. XM_063267323.1 → XP_063123393.1  ankyrin repeat and SOCS box protein 1 isoform X7

  6. XM_063267324.1 → XP_063123394.1  ankyrin repeat and SOCS box protein 1 isoform X8

    UniProtKB/TrEMBL
    A0A8I6AUV4

  7. XM_006245409.5 → XP_006245471.1  ankyrin repeat and SOCS box protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006245471.1

    UniProtKB/TrEMBL
    A6JQT2, F7F1S8
    Conserved Domains (5) summary
    cd00204
    Location:76 → 209
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd03720
    Location:291 → 332
    SOCS_ASB1; SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The ...
    pfam12796
    Location:79 → 170
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:34 → 95
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:76 → 105
    ANK; ANK repeat [structural motif]

  8. XM_063267321.1 → XP_063123391.1  ankyrin repeat and SOCS box protein 1 isoform X5

Nucleotide Protein Strain
Heading Accession and Version

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