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Resf1 retroelement silencing factor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316982, updated on 13-Apr-2024

Summary

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Official Symbol
Resf1provided by RGD
Official Full Name
retroelement silencing factor 1provided by RGD
Primary source
RGD:1309621
See related
Ensembl:ENSRNOG00000036913 AllianceGenome:RGD:1309621
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RGD1309621
Summary
Predicted to enable histone methyltransferase binding activity. Predicted to be involved in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate and positive regulation of DNA methylation-dependent heterochromatin assembly. Predicted to act upstream of or within response to bacterium. Predicted to be part of gamma-tubulin complex. Predicted to be active in nucleus. Orthologous to human RESF1 (retroelement silencing factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 253.1), Spleen (RPKM 247.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Resf1 in Genome Data Viewer
Location:
4q44
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (184057165..184093374)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (182325913..182362054)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (183879177..183905807)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene adenosylhomocysteinase-like Neighboring gene basic transcription factor 3, pseudogene 14 Neighboring gene uncharacterized LOC108350799 Neighboring gene ribosomal protein S8, pseudogene 18 Neighboring gene NSL1 component of MIS12 kinetochore complex, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A CRISPR knockout screen identifies SETDB1-target retroelement silencing factors in embryonic stem cells. Fukuda K, et al. Genome Res, 2018 Jun. PMID 29728365, Free PMC Article
  2. Impact of lactobacilli on orally acquired listeriosis. Archambaud C, et al. Proc Natl Acad Sci U S A, 2012 Oct 9. PMID 23012479, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables histone methyltransferase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone methyltransferase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of single stranded viral RNA replication via double stranded DNA intermediate ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA methylation-dependent heterochromatin formation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA methylation-dependent heterochromatin formation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to bacterium ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of gamma-tubulin complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
retroelement silencing factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427734.1 → NP_001414663.1  retroelement silencing factor 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    184057165..184093374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063286207.1 → XP_063142277.1  retroelement silencing factor 1 isoform X1

  2. XM_063286208.1 → XP_063142278.1  retroelement silencing factor 1 isoform X1

  3. XM_063286211.1 → XP_063142281.1  retroelement silencing factor 1 isoform X1

  4. XM_063286209.1 → XP_063142279.1  retroelement silencing factor 1 isoform X1

  5. XM_063286210.1 → XP_063142280.1  retroelement silencing factor 1 isoform X1

  6. XM_039108930.2 → XP_038964858.1  retroelement silencing factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZXS0, A6IN75
    Conserved Domains (1) summary
    pfam15395
    Location:447 → 1499
    DUF4617; Domain of unknown function (DUF4617)

  7. XM_039108935.2 → XP_038964863.1  retroelement silencing factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZXS0, A6IN75
    Conserved Domains (1) summary
    pfam15395
    Location:447 → 1499
    DUF4617; Domain of unknown function (DUF4617)

  8. XM_063286204.1 → XP_063142274.1  retroelement silencing factor 1 isoform X1

  9. XM_063286200.1 → XP_063142270.1  retroelement silencing factor 1 isoform X1

  10. XM_063286202.1 → XP_063142272.1  retroelement silencing factor 1 isoform X1

  11. XM_063286203.1 → XP_063142273.1  retroelement silencing factor 1 isoform X1

  12. XM_063286205.1 → XP_063142275.1  retroelement silencing factor 1 isoform X1

  13. XM_063286201.1 → XP_063142271.1  retroelement silencing factor 1 isoform X1

  14. XM_063286199.1 → XP_063142269.1  retroelement silencing factor 1 isoform X1

  15. XM_039108932.2 → XP_038964860.1  retroelement silencing factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZXS0, A6IN75
    Conserved Domains (1) summary
    pfam15395
    Location:447 → 1499
    DUF4617; Domain of unknown function (DUF4617)

  16. XM_039108933.2 → XP_038964861.1  retroelement silencing factor 1 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZXS0, A6IN75
    Conserved Domains (1) summary
    pfam15395
    Location:447 → 1499
    DUF4617; Domain of unknown function (DUF4617)

  17. XM_008763457.4 → XP_008761679.1  retroelement silencing factor 1 isoform X2

    See identical proteins and their annotated locations for XP_008761679.1

    UniProtKB/TrEMBL
    A0A8I5ZXS0, A6IN75, E9PU57
    Related
    ENSRNOP00000052305.5
    Conserved Domains (1) summary
    pfam15395
    Location:446 → 1457
    DUF4617; Domain of unknown function (DUF4617)

  18. XM_039108936.2 → XP_038964864.1  retroelement silencing factor 1 isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZXS0, A6IN75
    Conserved Domains (1) summary
    pfam15395
    Location:447 → 1366
    DUF4617; Domain of unknown function (DUF4617)

  19. XM_039108937.2 → XP_038964865.1  retroelement silencing factor 1 isoform X4

    UniProtKB/TrEMBL
    A0A8I5ZXS0, A6IN75
    Conserved Domains (1) summary
    pfam15395
    Location:447 → 1301
    DUF4617; Domain of unknown function (DUF4617)

  20. XM_063286206.1 → XP_063142276.1  retroelement silencing factor 1 isoform X1

  21. XM_006237708.5 → XP_006237770.1  retroelement silencing factor 1 isoform X1

    See identical proteins and their annotated locations for XP_006237770.1

    UniProtKB/TrEMBL
    A0A8I5ZXS0, A6IN75
    Conserved Domains (1) summary
    pfam15395
    Location:447 → 1499
    DUF4617; Domain of unknown function (DUF4617)

  22. XM_063286212.1 → XP_063142282.1  retroelement silencing factor 1 isoform X5

RNA

  1. XR_353788.5 RNA Sequence

  2. XR_010065651.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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