U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Zdhhc15 zinc finger DHHC-type palmitoyltransferase 15 [ Rattus norvegicus (Norway rat) ]

Gene ID: 317235, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Zdhhc15provided by RGD
Official Full Name
zinc finger DHHC-type palmitoyltransferase 15provided by RGD
Primary source
RGD:1562075
See related
Ensembl:ENSRNOG00000002751 AllianceGenome:RGD:1562075
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity and zinc ion binding activity. Involved in positive regulation of dendrite development; protein localization to postsynapse; and regulation of dendritic spine morphogenesis. Located in Golgi membrane and postsynapse. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 91. Orthologous to human ZDHHC15 (zinc finger DHHC-type palmitoyltransferase 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 64.8), Kidney (RPKM 42.8) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Zdhhc15 in Genome Data Viewer
Location:
Xq22
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (73633977..73767451, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (69568086..69701756, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (75433957..75566531, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily B member 7 Neighboring gene uracil phosphoribosyltransferase homolog Neighboring gene microRNA 3559 Neighboring gene U1 spliceosomal RNA Neighboring gene uncharacterized LOC102555916 Neighboring gene karyopherin subunit alpha 1, pseudogene 10 Neighboring gene MAGE family member E2 Neighboring gene small ribosomal subunit protein eS8-like

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Regulation of dendrite morphology and excitatory synapse formation by zDHHC15. Shah BS, et al. J Cell Sci, 2019 Jul 5. PMID 31189538, Free PMC Article
  2. Palmitoylation controls recycling in lysosomal sorting and trafficking. McCormick PJ, et al. Traffic, 2008 Nov. PMID 18817523, Free PMC Article
  3. Palmitoylation and membrane interactions of the neuroprotective chaperone cysteine-string protein. Greaves J, et al. J Biol Chem, 2008 Sep 5. PMID 18596047, Free PMC Article
  4. Identification of PSD-95 palmitoylating enzymes. Fukata M, et al. Neuron, 2004 Dec 16. PMID 15603741
  5. Analysis of substrate specificity of human DHHC protein acyltransferases using a yeast expression system. Ohno Y, et al. Mol Biol Cell, 2012 Dec. PMID 23034182, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-cysteine S-myristoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-palmitoyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-cysteine S-palmitoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-cysteine S-stearoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within establishment of protein localization ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of dendrite development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein localization to postsynapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
involved_in protein targeting to Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of dendritic spine morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synaptic vesicle maturation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within synaptic vesicle maturation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
palmitoyltransferase ZDHHC15
Names
DHHC-15
acyltransferase ZDHHC15
membrane-associated DHHC15 zinc finger protein
zinc finger DHHC domain-containing protein 15
zinc finger, DHHC domain containing 15
zinc finger, DHHC-type containing 15
NP_001034190.1
XP_006257207.1
XP_038955668.1
XP_063136095.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039101.1 → NP_001034190.1  palmitoyltransferase ZDHHC15

    See identical proteins and their annotated locations for NP_001034190.1

    Status: PROVISIONAL

    Source sequence(s)
    AY886531
    UniProtKB/Swiss-Prot
    Q2TGJ4
    Related
    ENSRNOP00000003714.5, ENSRNOT00000003714.6
    Conserved Domains (1) summary
    cl19890
    Location:125 → 308
    zf-DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    73633977..73767451 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006257145.5 → XP_006257207.1  palmitoyltransferase ZDHHC15 isoform X1

    See identical proteins and their annotated locations for XP_006257207.1

    UniProtKB/Swiss-Prot
    Q2TGJ4
    Conserved Domains (1) summary
    cl19890
    Location:125 → 308
    zf-DHHC; DHHC palmitoyltransferase

  2. XM_039099740.2 → XP_038955668.1  palmitoyltransferase ZDHHC15 isoform X2

    UniProtKB/TrEMBL
    A6IV19
    Conserved Domains (1) summary
    cl19890
    Location:17 → 200
    DHHC; DHHC palmitoyltransferase

  3. XM_063280025.1 → XP_063136095.1  palmitoyltransferase ZDHHC15 isoform X2

    UniProtKB/TrEMBL
    A6IV19
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2TGJ4.1 GenPept UniProtKB/Swiss-Prot:Q2TGJ4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous