Ercc6l ERCC excision repair 6 like, spindle assembly checkpoint helicase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ercc6lprovided by RGD
Official Full Name: ERCC excision repair 6 like, spindle assembly checkpoint helicaseprovided by RGD
Primary source: RGD:1565734
See related: Ensembl:ENSRNOG00000003208 AllianceGenome:RGD:1565734
Gene type: protein coding
RefSeq status: INFERRED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565734
Summary: Predicted to enable DNA translocase activity. Orthologous to human ERCC6L (ERCC excision repair 6 like, spindle assembly checkpoint helicase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 79.2), Spleen (RPKM 51.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq22

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (71285380..71301186, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (67245414..67261222, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (72018373..72034140, complement)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Characterization of the mouse Ercc6l ortholog.
Title: Ercc6l, a gene of SNF2 family, may play a role in the teratogenic action of alcohol.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent chromatin remodeler activity	IEA Inferred from Electronic Annotation more info
enables DNA translocase activity	IBA Inferred from Biological aspect of Ancestor more info
enables DNA translocase activity	ISO Inferred from Sequence Orthology more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA excision repair protein ERCC-6-like

Names: excision repair cross-complementation group 6-like; excision repair cross-complementing rodent repair deficiency complementation group 6 - like; excision repair cross-complementing rodent repair deficiency complementation group 6-like

NP_001092144.1

EC 3.6.4.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001098674.1 → NP_001092144.1 DNA excision repair protein ERCC-6-like

See identical proteins and their annotated locations for NP_001092144.1

Status: INFERRED

Source sequence(s)

JAXUCZ010000021

UniProtKB/TrEMBL

A0A8I6GF73, A6IQE3, D4A0G9

Related

ENSRNOP00000004310.4, ENSRNOT00000004310.7

Conserved Domains (3) summary

cd00046
Location:116 → 259

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

pfam00176
Location:99 → 417

SNF2_N; SNF2 family N-terminal domain

pfam00271
Location:461 → 576

Helicase_C; Helicase conserved C-terminal domain